DegronMD

Uniprot ID: Q9H165

Source protein: B-cell lymphoma/leukemia 11A

Source gene: BCL11A

Class: DEG_SCF_FBW7_1

Location: 147:154

E3 ligase: FBXW7

DEGRON score: 0.9465

ASA_SCORE: 82.7375

COIL: 0.8029

CONS_SCORE: 0.2425

DSS_SCORE: 0.448

HELIX: 0.0559

FCONS_SCORE: 0.9011

RIG_SCORE: 0.6654

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H144Y	TCGA-49-AARE	LUAD	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	0.25
p.H144Y	DO218922	LUAD	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.25
p.T150M	TCGA-A5-A2K7	UCEC	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	0.8534
p.A143T	TCGA-AJ-A3BH	UCEC	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	DO41638	UCEC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	SIDM00363	Acute Myeloid Leukemia	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	SIDM00531	Pancreatic Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	SIDM01617	Endometrial Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	ACH-000213	Pancreatic Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	ACH-000770	Leukemia	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	ACH-000994	Endometrial/Uterine Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	ACH-002263	Esophageal Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	HuP-T4	pancreas	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.A143T	KYSE-220	oesophagus	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.P159L	TCGA-D3-A3MR	SKCM	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	0.1944
p.P159L	SIDM00680	Colorectal Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	0.1944
p.P159L	ACH-000957	Colon/Colorectal Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	0.1944
p.P159L	LS-180	large_intestine	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.1944
p.P151T	TCGA-DX-A6YV	SARC	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	0.7031
p.P151T	DO220011	SARC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.7031
p.P140L	TCGA-FW-A3R5	SKCM	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	0.1389
p.P140L	DO37406	SKCM	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.1389
p.R141P	TCGA-UF-A71A	HNSC	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	0.1667
p.R141P	DO52106	HNSC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.1667
p.G145E	TCGA-XK-AAIW	PRAD	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	0.2778
p.G145E	DO51407	PRAD	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.2778
p.E142K	DO4221	BRCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.1944
p.E142K	DO23194	LINC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.1944
p.P149L	DO7962	COAD	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.6471
p.D144N	DO8490	COAD	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.25
p.A137T	DO222755	COCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.0556
p.S138Y	DO229019	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.0833
p.F139L	DO229031	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.1111
p.T150K	DO229045	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.8417
p.N143K	DO229056	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.2222
p.R141S	DO229006	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.1667
p.E161K	DO26560	LUSC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.1389
p.E161K	DO229459	SKCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.1389
p.D160N	DO222363	MELA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.1667
p.E154K	DO218863	SKCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.7022
p.G152W	DO40045	THCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	0.6714
p.G161C	SIDM00535	Chondrosarcoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	0.1389
p.G161C	ACH-001519	Bone Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	0.1389
p.G161C	H-EMC-SS	bone	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.1389
p.S142F	SIDM00772	Breast Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	0.1944
p.S142F	ACH-000755	Breast Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	0.1944
p.S142F	HCC2218	breast	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.1944
p.A155T	ACH-001518	Endometrial/Uterine Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	0.3056
p.G160R	ACH-002272	Lymphoma	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	0.1667
p.G160R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.1667
p.A141T	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.1667
p.A141T	HuP-T4	pancreas	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.1667
p.A141T	KYSE-220	oesophagus	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.1667
p.P157L	LS-180	large_intestine	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.25
p.S140F	HCC2218	breast	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.1389
p.G159C	H-EMC-SS	bone	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LIPTPGMS

Degron related mutations and impact score

Drug responses associated with BCL11A mutations

All proteins holding degron of LIPTPGMS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H165	B-cell lymphoma/leukemia 11A	DEG_SCF_FBW7_1	147:154	LIPTPGMS	FBXW7	0.9465	More...