DegronMD - Q9H165(BCL11A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H144Y	TCGA-49-AARE	LUAD	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.25
p.H144Y	DO218922	LUAD	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.25
p.R196I	TCGA-A5-A2K5	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6991
p.T150M	TCGA-A5-A2K7	UCEC	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.8534
p.A143T	TCGA-AJ-A3BH	UCEC	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	DO41638	UCEC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	SIDM00363	Acute Myeloid Leukemia	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	SIDM00531	Pancreatic Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	SIDM01617	Endometrial Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	ACH-000213	Pancreatic Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	ACH-000770	Leukemia	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	ACH-000994	Endometrial/Uterine Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	ACH-002263	Esophageal Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	HuP-T4	pancreas	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.A143T	KYSE-220	oesophagus	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.R196T	TCGA-AO-A129	BRCA	TCGA	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6765
p.A189T	TCGA-AP-A051	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.A189T	TCGA-AX-A05Z	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.L185I	TCGA-AP-A056	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.0556
p.R210W	TCGA-AX-A1CE	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.0556
p.R210W	SIDM01201	Other Blood Cancers	GDSC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.0556
p.R210W	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.0556
p.P159L	TCGA-D3-A3MR	SKCM	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.P159L	SIDM00680	Colorectal Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.P159L	ACH-000957	Colon/Colorectal Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.P159L	LS-180	large intestine	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.P151T	TCGA-DX-A6YV	SARC	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.7031
p.P151T	DO220011	SARC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.7031
p.P206L	TCGA-ER-A19F	SKCM	TCGA	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.P140L	TCGA-FW-A3R5	SKCM	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1389
p.P140L	DO37406	SKCM	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1389
p.R141P	TCGA-UF-A71A	HNSC	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1667
p.R141P	DO52106	HNSC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1667
p.G204E	TCGA-WE-A8ZT	SKCM	TCGA	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2222
p.G204R	TCGA-WE-A8ZT	SKCM	TCGA	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2222
p.G145E	TCGA-XK-AAIW	PRAD	TCGA	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2778
p.G145E	DO51407	PRAD	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2778
p.E142K	DO4221	BRCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.E142K	DO23194	LINC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.P149L	DO7962	COAD	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.6471
p.D144N	DO8490	COAD	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.25
p.A190V	DO227979	COCA	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1944
p.A137T	DO222755	COCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.0556
p.R192H	DO222737	COCA	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.R192H	DO41199	UCEC	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.E195G	DO234262	ESAD	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7199
p.S198L	DO233089	GACA	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7667
p.S198L	DO51274	SKCM	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7667
p.R192C	DO233950	GACA	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.A201T	DO13635	GBM	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation blocking phosphorylation signal	0.75
p.N201D	DO13851	GBM	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation blocking phosphorylation signal	0.75
p.P203L	DO11854	GBM	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.A199E	DO228986	LICA	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7701
p.S138Y	DO229019	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.0833
p.N196K	DO229028	LICA	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.6918
p.F139L	DO229031	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1111
p.T150K	DO229045	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.8417
p.N143K	DO229056	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.2222
p.R141S	DO229006	LICA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1667
p.G206S	DO223912	LIHC	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.N205Y	DO231718	LINC	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation blocking phosphorylation signal	0.6389
p.G195V	DO26337	LUAD	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7532
p.E161K	DO26560	LUSC	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1389
p.E161K	DO229459	SKCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1389
p.S209I	DO27699	LUSC	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.0833
p.E195K	DO220900	MELA	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7022
p.D160N	DO222363	MELA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1667
p.A201V	DO49145	PACA	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation blocking phosphorylation signal	0.75
p.P210S	DO51407	PRAD	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.0556
p.R210H	DO220201	SARC	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.0556
p.E154K	DO218863	SKCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.7022
p.E208K	DO50284	SKCM	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation blocking phosphorylation signal	0.5556
p.G152W	DO40045	THCA	ICGC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.6714
p.A199T	DO42472	UCEC	ICGC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7139
p.G194R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.3056
p.G194R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.3056
p.G161C	SIDM00535	Chondrosarcoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1389
p.G161C	ACH-001519	Bone Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1389
p.G161C	H-EMC-SS	bone	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1389
p.S142F	SIDM00772	Breast Carcinoma	GDSC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.S142F	ACH-000755	Breast Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.S142F	HCC2218	breast	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.A155T	ACH-001518	Endometrial/Uterine Cancer	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.3056
p.G160R	ACH-002272	Lymphoma	CCLE	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1667
p.G160R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1667
p.G192R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.25
p.R208W	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation blocking phosphorylation signal	0.5556
p.A141T	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1667
p.A141T	HuP-T4	pancreas	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1667
p.A141T	KYSE-220	oesophagus	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1667
p.P157L	LS-180	large intestine	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.25
p.N202D	PF-382	haematopoietic and lymphoid tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2778
p.R197Q	LoVo	large intestine	COSMIC	LRIYLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.7329
p.S140F	HCC2218	breast	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1389
p.G159C	H-EMC-SS	bone	COSMIC	LIPTPGMS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BCL11A

UniProt ID: Q9H165

Entrez ID: 53335

Protein name: B-cell lymphoma/leukemia 11A (BCL-11A) (B-cell CLL/lymphoma 11A) (COUP-TF-interacting protein 1) (Ecotropic viral integration site 9 protein homolog) (EVI-9) (Zinc finger protein 856)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BCL11A in