DegronMD

Uniprot ID: Q9H165

Source protein: B-cell lymphoma/leukemia 11A

Source gene: BCL11A

Class: LIG_APCC_ABBA_1

Location: 195:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9942

ASA_SCORE: 70.7833

COIL: 0.701

CONS_SCORE: 0.4769

DSS_SCORE: 0.3886

HELIX: 0.0245

FCONS_SCORE: 0.9504

RIG_SCORE: 0.8001

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R196I	TCGA-A5-A2K5	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	0.6991
p.R196T	TCGA-AO-A129	BRCA	TCGA	LRIYLE	LIG_APCC_ABBA_1	0.6765
p.A189T	TCGA-AP-A051	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	0.1667
p.A189T	TCGA-AX-A05Z	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	0.1667
p.L185I	TCGA-AP-A056	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	0.0556
p.R210W	TCGA-AX-A1CE	UCEC	TCGA	LRIYLE	LIG_APCC_ABBA_1	0.0556
p.R210W	SIDM01201	Other Blood Cancers	GDSC	LRIYLE	LIG_APCC_ABBA_1	0.0556
p.R210W	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	0.0556
p.P206L	TCGA-ER-A19F	SKCM	TCGA	LRIYLE	LIG_APCC_ABBA_1	0.1667
p.G204E	TCGA-WE-A8ZT	SKCM	TCGA	LRIYLE	LIG_APCC_ABBA_1	0.2222
p.G204R	TCGA-WE-A8ZT	SKCM	TCGA	LRIYLE	LIG_APCC_ABBA_1	0.2222
p.A190V	DO227979	COCA	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.1944
p.R192H	DO222737	COCA	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.25
p.R192H	DO41199	UCEC	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.25
p.E195G	DO234262	ESAD	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.7199
p.S198L	DO233089	GACA	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.7667
p.S198L	DO51274	SKCM	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.7667
p.R192C	DO233950	GACA	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.25
p.A201T	DO13635	GBM	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.75
p.N201D	DO13851	GBM	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.75
p.P203L	DO11854	GBM	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.25
p.A199E	DO228986	LICA	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.7701
p.N196K	DO229028	LICA	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.6918
p.G206S	DO223912	LIHC	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.1667
p.N205Y	DO231718	LINC	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.6389
p.G195V	DO26337	LUAD	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.7532
p.S209I	DO27699	LUSC	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.0833
p.E195K	DO220900	MELA	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.7022
p.A201V	DO49145	PACA	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.75
p.P210S	DO51407	PRAD	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.0556
p.R210H	DO220201	SARC	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.0556
p.E208K	DO50284	SKCM	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.5556
p.A199T	DO42472	UCEC	ICGC	LRIYLE	LIG_APCC_ABBA_1	0.7139
p.G194R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LRIYLE	LIG_APCC_ABBA_1	0.3056
p.G194R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	0.3056
p.G192R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	0.25
p.R208W	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	0.5556
p.N202D	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LRIYLE	LIG_APCC_ABBA_1	0.2778
p.R197Q	LoVo	large_intestine	COSMIC	LRIYLE	LIG_APCC_ABBA_1	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRIYLE

Degron related mutations and impact score

Drug responses associated with BCL11A mutations

All proteins holding degron of LRIYLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H165	B-cell lymphoma/leukemia 11A	LIG_APCC_ABBA_1	195:200	LRIYLE	APC,CDC20,FZR1	0.9942	More...