DegronMD

Uniprot ID: Q9BVJ6

Source protein: U3 small nucleolar RNA-associated protein 14 homolog A

Source gene: UTP14A

Class: DEG_APCC_KENBOX_2

Location: 467:471

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8597

ASA_SCORE: 105.84

COIL: 0.4094

CONS_SCORE: 0.22

DSS_SCORE: 0.6138

HELIX: 0.5902

FCONS_SCORE: 1.0202

RIG_SCORE: 0.65

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E481Q	TCGA-62-8399	LUAD	TCGA	LKENH	DEG_APCC_KENBOX_2	0.0556
p.H471Y	TCGA-XC-AA0X	LUSC	TCGA	LKENH	DEG_APCC_KENBOX_2	0.6118
p.E461A	DO2943	BRCA	ICGC	LKENH	DEG_APCC_KENBOX_2	0.1667
p.E480K	DO6347	CESC	ICGC	LKENH	DEG_APCC_KENBOX_2	0.5278
p.L479F	DO52205	LIHC	ICGC	LKENH	DEG_APCC_KENBOX_2	0.5556
p.E466K	DO222880	MELA	ICGC	LKENH	DEG_APCC_KENBOX_2	0.3056
p.E480A	DO42129	UCEC	ICGC	LKENH	DEG_APCC_KENBOX_2	0.5278
p.E461K	DO42033	UCEC	ICGC	LKENH	DEG_APCC_KENBOX_2	0.1667
p.P475T	DO43578	UCEC	ICGC	LKENH	DEG_APCC_KENBOX_2	0.3333
p.P475H	DO41752	UCEC	ICGC	LKENH	DEG_APCC_KENBOX_2	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVJ6	U3 small nucleolar RNA-associated protein 14 homolog A	DEG_APCC_KENBOX_2	467:471	LKENH	APC,CDC20,FZR1	0.8597	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons