DegronMD - Q9BVJ6(UTP14A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E351K	TCGA-55-A48X	LUAD	TCGA	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation altering degron motif	0.7022
p.E481Q	TCGA-62-8399	LUAD	TCGA	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation rewiring degron network	0.0556
p.E735Q	TCGA-77-8136	LUSC	TCGA	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation rewiring degron network	0.1111
p.S571F	TCGA-90-A4ED	LUSC	TCGA	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.9093
p.E364K	TCGA-A5-A2K5	UCEC	TCGA	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.25
p.Q562H	TCGA-AJ-A3EK	UCEC	TCGA	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation rewiring degron network	0.0833
p.F695S	TCGA-AP-A059	UCEC	TCGA	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation rewiring degron network	0.2222
p.S705F	TCGA-AP-A1DV	UCEC	TCGA	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation altering degron motif	0.7982
p.S705F	TCGA-CV-7568	HNSC	TCGA	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation altering degron motif	0.7982
p.S574Y	TCGA-B5-A1MR	UCEC	TCGA	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.712
p.D352Y	TCGA-BG-A0VX	UCEC	TCGA	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation altering degron motif	0.6214
p.E346D	TCGA-BS-A0UF	UCEC	TCGA	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.2222
p.L357I	TCGA-D3-A1Q3	SKCM	TCGA	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation altering degron motif	0.6063
p.Q751H	TCGA-D3-A2JP	SKCM	TCGA	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation altering degron motif	0.647
p.N753I	TCGA-E2-A14V	BRCA	TCGA	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation rewiring degron network	0.2778
p.P578S	TCGA-EE-A2GO	SKCM	TCGA	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.6752
p.E586G	TCGA-F7-A624	HNSC	TCGA	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation rewiring degron network	0.1667
p.E588D	TCGA-HC-7081	PRAD	TCGA	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation rewiring degron network	0.1111
p.V572M	TCGA-NH-A5IV	COAD	TCGA	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.6097
p.V572M	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.6097
p.H471Y	TCGA-XC-AA0X	LUSC	TCGA	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation altering degron motif	0.6118
p.M367I	TCGA-ZJ-A8QR	CESC	TCGA	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.1667
p.E346K	DO48442	BLCA	ICGC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.2222
p.E340K	DO219002	BLCA	ICGC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.0556
p.E461A	DO2943	BRCA	ICGC	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation rewiring degron network	0.1667
p.N699I	DO3548	BRCA	ICGC	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation altering degron motif	0.728
p.L342R	DO222838	BTCA	ICGC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.1111
p.E362Q	DO49976	CESC	ICGC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.3056
p.E480K	DO6347	CESC	ICGC	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation blocking phosphorylation signal	0.5278
p.E579K	DO228581	GACA	ICGC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.7022
p.E563D	DO228971	LICA	ICGC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation rewiring degron network	0.1111
p.A589S	DO229031	LICA	ICGC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation rewiring degron network	0.0833
p.L479F	DO52205	LIHC	ICGC	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation blocking phosphorylation signal	0.5556
p.V583L	DO26764	LUSC	ICGC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation rewiring degron network	0.25
p.E466K	DO222880	MELA	ICGC	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation rewiring degron network	0.3056
p.K590N	DO232761	PBCA	ICGC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation rewiring degron network	0.0556
p.Q697H	DO47407	SKCM	ICGC	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation rewiring degron network	0.2778
p.E354D	DO48547	STAD	ICGC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation altering degron motif	0.5647
p.G349R	DO38723	STAD	ICGC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.3056
p.F370C	DO47743	STAD	ICGC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.0833
p.K708Q	DO219771	UCEC	ICGC	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation rewiring degron network	0.25
p.E480A	DO42129	UCEC	ICGC	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation blocking phosphorylation signal	0.5278
p.E461K	DO42033	UCEC	ICGC	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation rewiring degron network	0.1667
p.P359S	DO42312	UCEC	ICGC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation altering degron motif	0.6752
p.P475T	DO43578	UCEC	ICGC	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation substituting flanking lysine	0.3333
p.K709Q	DO43186	UCEC	ICGC	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation rewiring degron network	0.2222
p.P475H	DO41752	UCEC	ICGC	LKENH	DEG_APCC_KENBOX_2	467:471	Mutation substituting flanking lysine	0.3333
p.A347V	DO41542	UCEC	ICGC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.25
p.N753H	SIDM01141	Ovarian Carcinoma	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation rewiring degron network	0.2778
p.N753H	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation rewiring degron network	0.2778
p.N753H	SIDM01044	Other Solid Cancers	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation rewiring degron network	0.2778
p.H691N	SIDM00781	Colorectal Carcinoma	GDSC	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation rewiring degron network	0.1111
p.H691N	ACH-001199	Colon/Colorectal Cancer	CCLE	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation rewiring degron network	0.1111
p.H691N	SNU-C2B	large intestine	COSMIC	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation rewiring degron network	0.1111
p.I580L	SIDM00284	Melanoma	GDSC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.6063
p.I580L	ACH-000805	Skin Cancer	CCLE	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.6063
p.I580L	COLO-679	skin	COSMIC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.6063
p.I580K	SIDM00284	Melanoma	GDSC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.7531
p.I580K	ACH-000805	Skin Cancer	CCLE	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.7531
p.I580K	COLO-679	skin	COSMIC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.7531
p.N363I	SIDM01088	Endometrial Carcinoma	GDSC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.2778
p.N363I	ACH-000965	Endometrial/Uterine Cancer	CCLE	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.2778
p.N363I	RL95-2	endometrium	COSMIC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.2778
p.A734V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation rewiring degron network	0.0833
p.A734V	ACH-000855	Esophageal Cancer	CCLE	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation rewiring degron network	0.0833
p.A734V	KYSE-150	oesophagus	COSMIC	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation rewiring degron network	0.0833
p.R744S	SIDM01609	Endometrial Carcinoma	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation altering degron motif	0.7427
p.R744S	ACH-000972	Endometrial/Uterine Cancer	CCLE	SRSDLSVIQ	DEG_APCC_DBOX_1	743:751	Mutation altering degron motif	0.7427
p.L561I	ACH-001061	Colon/Colorectal Cancer	CCLE	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation rewiring degron network	0.0556
p.F713L	ACH-002396	Bone Cancer	CCLE	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation rewiring degron network	0.1111
p.F713L	Sarc9371	bone	COSMIC	IQTPIGS	DEG_SCF_FBW7_1	699:705	Mutation rewiring degron network	0.1111
p.R561M	CW-2	large intestine	COSMIC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation rewiring degron network	0.0556
p.E348A	RKO	large intestine	COSMIC	TEDVEELLVPDV	DEG_COP1_1	350:361	Mutation rewiring degron network	0.2778
p.D571N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	SVKSLAVPTI	DEG_COP1_1	571:580	Mutation altering degron motif	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UTP14A

UniProt ID: Q9BVJ6

Entrez ID: 10813

Protein name: U3 small nucleolar RNA-associated protein 14 homolog A (Antigen NY-CO-16) (Serologically defined colon cancer antigen 16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UTP14A in