DegronMD

Uniprot ID: Q9BVJ6

Source protein: U3 small nucleolar RNA-associated protein 14 homolog A

Source gene: UTP14A

Class: DEG_COP1_1

Location: 571:580

E3 ligase: COP1

DEGRON score: 0.9434

ASA_SCORE: 82.77

COIL: 0.7684

CONS_SCORE: 0.2004

DSS_SCORE: 0.5359

HELIX: 0.1185

FCONS_SCORE: 0.762

RIG_SCORE: 0.721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S571F	TCGA-90-A4ED	LUSC	TCGA	SVKSLAVPTI	DEG_COP1_1	0.9093
p.Q562H	TCGA-AJ-A3EK	UCEC	TCGA	SVKSLAVPTI	DEG_COP1_1	0.0833
p.S574Y	TCGA-B5-A1MR	UCEC	TCGA	SVKSLAVPTI	DEG_COP1_1	0.712
p.P578S	TCGA-EE-A2GO	SKCM	TCGA	SVKSLAVPTI	DEG_COP1_1	0.6752
p.E586G	TCGA-F7-A624	HNSC	TCGA	SVKSLAVPTI	DEG_COP1_1	0.1667
p.E588D	TCGA-HC-7081	PRAD	TCGA	SVKSLAVPTI	DEG_COP1_1	0.1111
p.V572M	TCGA-NH-A5IV	COAD	TCGA	SVKSLAVPTI	DEG_COP1_1	0.6097
p.V572M	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	SVKSLAVPTI	DEG_COP1_1	0.6097
p.E579K	DO228581	GACA	ICGC	SVKSLAVPTI	DEG_COP1_1	0.7022
p.E563D	DO228971	LICA	ICGC	SVKSLAVPTI	DEG_COP1_1	0.1111
p.A589S	DO229031	LICA	ICGC	SVKSLAVPTI	DEG_COP1_1	0.0833
p.V583L	DO26764	LUSC	ICGC	SVKSLAVPTI	DEG_COP1_1	0.25
p.K590N	DO232761	PBCA	ICGC	SVKSLAVPTI	DEG_COP1_1	0.0556
p.I580L	SIDM00284	Melanoma	GDSC	SVKSLAVPTI	DEG_COP1_1	0.6063
p.I580L	ACH-000805	Skin Cancer	CCLE	SVKSLAVPTI	DEG_COP1_1	0.6063
p.I580L	COLO-679	skin	COSMIC	SVKSLAVPTI	DEG_COP1_1	0.6063
p.I580K	SIDM00284	Melanoma	GDSC	SVKSLAVPTI	DEG_COP1_1	0.7531
p.I580K	ACH-000805	Skin Cancer	CCLE	SVKSLAVPTI	DEG_COP1_1	0.7531
p.I580K	COLO-679	skin	COSMIC	SVKSLAVPTI	DEG_COP1_1	0.7531
p.L561I	ACH-001061	Colon/Colorectal Cancer	CCLE	SVKSLAVPTI	DEG_COP1_1	0.0556
p.R561M	CW-2	large_intestine	COSMIC	SVKSLAVPTI	DEG_COP1_1	0.0556
p.D571N	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	SVKSLAVPTI	DEG_COP1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVJ6	U3 small nucleolar RNA-associated protein 14 homolog A	DEG_COP1_1	571:580	SVKSLAVPTI	COP1	0.9434	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons