DegronMD

Uniprot ID: Q9BVJ6

Source protein: U3 small nucleolar RNA-associated protein 14 homolog A

Source gene: UTP14A

Class: DEG_APCC_DBOX_1

Location: 743:751

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9093

ASA_SCORE: 86.6

COIL: 0.54

CONS_SCORE: 0.1774

DSS_SCORE: 0.5406

HELIX: 0.4411

FCONS_SCORE: 0.7535

RIG_SCORE: 0.7245

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E735Q	TCGA-77-8136	LUSC	TCGA	SRSDLSVIQ	DEG_APCC_DBOX_1	0.1111
p.Q751H	TCGA-D3-A2JP	SKCM	TCGA	SRSDLSVIQ	DEG_APCC_DBOX_1	0.647
p.N753I	TCGA-E2-A14V	BRCA	TCGA	SRSDLSVIQ	DEG_APCC_DBOX_1	0.2778
p.N753H	SIDM01141	Ovarian Carcinoma	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	0.2778
p.N753H	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	0.2778
p.N753H	SIDM01044	Other Solid Cancers	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	0.2778
p.A734V	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	0.0833
p.A734V	ACH-000855	Esophageal Cancer	CCLE	SRSDLSVIQ	DEG_APCC_DBOX_1	0.0833
p.A734V	KYSE-150	oesophagus	COSMIC	SRSDLSVIQ	DEG_APCC_DBOX_1	0.0833
p.R744S	SIDM01609	Endometrial Carcinoma	GDSC	SRSDLSVIQ	DEG_APCC_DBOX_1	0.7427
p.R744S	ACH-000972	Endometrial/Uterine Cancer	CCLE	SRSDLSVIQ	DEG_APCC_DBOX_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVJ6	U3 small nucleolar RNA-associated protein 14 homolog A	DEG_APCC_DBOX_1	743:751	SRSDLSVIQ	APC,CDC20,FZR1	0.9093	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons