DegronMD

Uniprot ID: Q9BVJ6

Source protein: U3 small nucleolar RNA-associated protein 14 homolog A

Source gene: UTP14A

Class: DEG_COP1_1

Location: 350:361

E3 ligase: COP1

DEGRON score: 0.9824

ASA_SCORE: 87.5833

COIL: 0.6453

CONS_SCORE: 0.284

DSS_SCORE: 0.6301

HELIX: 0.3242

FCONS_SCORE: 1.0102

RIG_SCORE: 0.7909

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E351K	TCGA-55-A48X	LUAD	TCGA	TEDVEELLVPDV	DEG_COP1_1	0.7022
p.E364K	TCGA-A5-A2K5	UCEC	TCGA	TEDVEELLVPDV	DEG_COP1_1	0.25
p.D352Y	TCGA-BG-A0VX	UCEC	TCGA	TEDVEELLVPDV	DEG_COP1_1	0.6214
p.E346D	TCGA-BS-A0UF	UCEC	TCGA	TEDVEELLVPDV	DEG_COP1_1	0.2222
p.L357I	TCGA-D3-A1Q3	SKCM	TCGA	TEDVEELLVPDV	DEG_COP1_1	0.6063
p.M367I	TCGA-ZJ-A8QR	CESC	TCGA	TEDVEELLVPDV	DEG_COP1_1	0.1667
p.E346K	DO48442	BLCA	ICGC	TEDVEELLVPDV	DEG_COP1_1	0.2222
p.E340K	DO219002	BLCA	ICGC	TEDVEELLVPDV	DEG_COP1_1	0.0556
p.L342R	DO222838	BTCA	ICGC	TEDVEELLVPDV	DEG_COP1_1	0.1111
p.E362Q	DO49976	CESC	ICGC	TEDVEELLVPDV	DEG_COP1_1	0.3056
p.E354D	DO48547	STAD	ICGC	TEDVEELLVPDV	DEG_COP1_1	0.5647
p.G349R	DO38723	STAD	ICGC	TEDVEELLVPDV	DEG_COP1_1	0.3056
p.F370C	DO47743	STAD	ICGC	TEDVEELLVPDV	DEG_COP1_1	0.0833
p.P359S	DO42312	UCEC	ICGC	TEDVEELLVPDV	DEG_COP1_1	0.6752
p.A347V	DO41542	UCEC	ICGC	TEDVEELLVPDV	DEG_COP1_1	0.25
p.N363I	SIDM01088	Endometrial Carcinoma	GDSC	TEDVEELLVPDV	DEG_COP1_1	0.2778
p.N363I	ACH-000965	Endometrial/Uterine Cancer	CCLE	TEDVEELLVPDV	DEG_COP1_1	0.2778
p.N363I	RL95-2	endometrium	COSMIC	TEDVEELLVPDV	DEG_COP1_1	0.2778
p.E348A	RKO	large_intestine	COSMIC	TEDVEELLVPDV	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVJ6	U3 small nucleolar RNA-associated protein 14 homolog A	DEG_COP1_1	350:361	TEDVEELLVPDV	COP1	0.9824	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons