DegronMD

Uniprot ID: Q9BVJ6

Source protein: U3 small nucleolar RNA-associated protein 14 homolog A

Source gene: UTP14A

Class: DEG_SCF_FBW7_1

Location: 699:705

E3 ligase: FBXW7

DEGRON score: 0.9245

ASA_SCORE: 42.6143

COIL: 0.7707

CONS_SCORE: 0.5374

DSS_SCORE: 0.3759

HELIX: 0.1874

FCONS_SCORE: 1.0417

RIG_SCORE: 0.7852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F695S	TCGA-AP-A059	UCEC	TCGA	IQTPIGS	DEG_SCF_FBW7_1	0.2222
p.S705F	TCGA-AP-A1DV	UCEC	TCGA	IQTPIGS	DEG_SCF_FBW7_1	0.7982
p.S705F	TCGA-CV-7568	HNSC	TCGA	IQTPIGS	DEG_SCF_FBW7_1	0.7982
p.N699I	DO3548	BRCA	ICGC	IQTPIGS	DEG_SCF_FBW7_1	0.728
p.Q697H	DO47407	SKCM	ICGC	IQTPIGS	DEG_SCF_FBW7_1	0.2778
p.K708Q	DO219771	UCEC	ICGC	IQTPIGS	DEG_SCF_FBW7_1	0.25
p.K709Q	DO43186	UCEC	ICGC	IQTPIGS	DEG_SCF_FBW7_1	0.2222
p.H691N	SIDM00781	Colorectal Carcinoma	GDSC	IQTPIGS	DEG_SCF_FBW7_1	0.1111
p.H691N	ACH-001199	Colon/Colorectal Cancer	CCLE	IQTPIGS	DEG_SCF_FBW7_1	0.1111
p.H691N	SNU-C2B	large_intestine	COSMIC	IQTPIGS	DEG_SCF_FBW7_1	0.1111
p.F713L	ACH-002396	Bone Cancer	CCLE	IQTPIGS	DEG_SCF_FBW7_1	0.1111
p.F713L	Sarc9371	bone	COSMIC	IQTPIGS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TAP6	U3 small nucleolar RNA-associated protein 14 homolog C	DEG_SCF_FBW7_1	698:704	IQTPIGS	FBXW7	0.9726	More...
Q9BVJ6	U3 small nucleolar RNA-associated protein 14 homolog A	DEG_SCF_FBW7_1	699:705	IQTPIGS	FBXW7	0.9245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons