DegronMD

Uniprot ID: Q5TAP6

Source protein: U3 small nucleolar RNA-associated protein 14 homolog C

Source gene: UTP14C

Class: DEG_SCF_FBW7_1

Location: 698:704

E3 ligase: FBXW7

DEGRON score: 0.9726

ASA_SCORE: 46.9857

COIL: 0.7803

CONS_SCORE: 0.5335

DSS_SCORE: 0.4617

HELIX: 0.174

FCONS_SCORE: 1.0344

RIG_SCORE: 0.7606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R692W	TCGA-C5-A1MF	CESC	TCGA	IQTPIGS	DEG_SCF_FBW7_1	0.1667
p.R692W	DO6251	CESC	ICGC	IQTPIGS	DEG_SCF_FBW7_1	0.1667
p.I698M	TCGA-DC-6157	READ	TCGA	IQTPIGS	DEG_SCF_FBW7_1	0.6507
p.I698M	DO36383	READ	ICGC	IQTPIGS	DEG_SCF_FBW7_1	0.6507
p.E695Q	TCGA-FD-A3B7	BLCA	TCGA	IQTPIGS	DEG_SCF_FBW7_1	0.25
p.E695Q	DO572	BLCA	ICGC	IQTPIGS	DEG_SCF_FBW7_1	0.25
p.P701H	DO45141	LIRI	ICGC	IQTPIGS	DEG_SCF_FBW7_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TAP6	U3 small nucleolar RNA-associated protein 14 homolog C	DEG_SCF_FBW7_1	698:704	IQTPIGS	FBXW7	0.9726	More...
Q9BVJ6	U3 small nucleolar RNA-associated protein 14 homolog A	DEG_SCF_FBW7_1	699:705	IQTPIGS	FBXW7	0.9245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons