DegronMD - Q5TAP6(UTP14C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P576S	TCGA-06-5416	GBM	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6752
p.P576S	DO233759	GACA	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6752
p.P576S	DO10880	GBM	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6752
p.P576S	DO233295	NACA	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6752
p.S569F	TCGA-18-3409	LUSC	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.7982
p.S569F	DO26444	LUSC	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.7982
p.E581Q	TCGA-21-1077	LUSC	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation rewiring degron network	0.25
p.E581Q	DO26725	LUSC	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation rewiring degron network	0.25
p.N561H	TCGA-A5-A1OF	UCEC	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation rewiring degron network	0.1111
p.N561H	DO42568	UCEC	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation rewiring degron network	0.1111
p.S572Y	TCGA-AG-A002	READ	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.712
p.S572Y	TCGA-BK-A6W3	UCEC	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.712
p.S572Y	DO50076	UCEC	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.712
p.S572Y	SIDM01611	Endometrial Carcinoma	GDSC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.712
p.S572Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.712
p.G737D	TCGA-B5-A3F9	UCEC	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.1944
p.G737D	DO52401	UCEC	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.1944
p.R759C	TCGA-B5-A3FC	UCEC	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.0833
p.R759C	TCGA-R5-A7ZI	STAD	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.0833
p.R759C	DO233089	GACA	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.0833
p.R759C	DO222342	STAD	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.0833
p.R759C	DO41871	UCEC	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.0833
p.D735Y	TCGA-B6-A0I8	BRCA	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.1389
p.D735Y	DO2149	BRCA	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.1389
p.A574T	TCGA-BR-8363	STAD	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6028
p.A574T	DO232761	PBCA	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6028
p.A574T	DO47837	STAD	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6028
p.R692W	TCGA-C5-A1MF	CESC	TCGA	IQTPIGS	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.1667
p.R692W	DO6251	CESC	ICGC	IQTPIGS	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.1667
p.V570M	TCGA-CK-5916	COAD	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6097
p.V570M	DO8786	COAD	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6097
p.S380N	TCGA-CU-A0YN	BLCA	TCGA	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation rewiring degron network	0.1389
p.S380N	DO488	BLCA	ICGC	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation rewiring degron network	0.1389
p.P391T	TCGA-DA-A1I2	SKCM	TCGA	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation altering degron motif	0.5919
p.P391T	DO37758	SKCM	ICGC	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation altering degron motif	0.5919
p.I698M	TCGA-DC-6157	READ	TCGA	IQTPIGS	DEG_SCF_FBW7_1	698:704	Mutation altering degron motif	0.6507
p.I698M	DO36383	READ	ICGC	IQTPIGS	DEG_SCF_FBW7_1	698:704	Mutation altering degron motif	0.6507
p.Q750R	TCGA-DF-A2KU	UCEC	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation altering degron motif	0.6218
p.Q750R	DO223286	UCEC	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation altering degron motif	0.6218
p.E695Q	TCGA-FD-A3B7	BLCA	TCGA	IQTPIGS	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.25
p.E695Q	DO572	BLCA	ICGC	IQTPIGS	DEG_SCF_FBW7_1	698:704	Mutation rewiring degron network	0.25
p.S742L	TCGA-FD-A3SS	BLCA	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation altering degron motif	0.7667
p.S742L	DO737	BLCA	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation altering degron motif	0.7667
p.S403F	TCGA-FW-A3R5	SKCM	TCGA	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation rewiring degron network	0.1667
p.S403F	DO37406	SKCM	ICGC	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation rewiring degron network	0.1667
p.V570L	TCGA-L9-A7SV	LUAD	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.5654
p.V570L	DO49875	LUAD	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.5654
p.D584H	TCGA-Q1-A73O	CESC	TCGA	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation rewiring degron network	0.1667
p.D584H	DO51612	CESC	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation rewiring degron network	0.1667
p.V736L	TCGA-V4-A9EI	UVM	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.1667
p.S405R	DO222397	BTCA	ICGC	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation rewiring degron network	0.1111
p.V394M	DO222623	BTCA	ICGC	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation altering degron motif	0.7208
p.F562L	DO222884	COCA	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation rewiring degron network	0.1389
p.E384D	DO229019	LICA	ICGC	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation rewiring degron network	0.25
p.R588I	DO229008	LICA	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation rewiring degron network	0.0556
p.P701H	DO45141	LIRI	ICGC	IQTPIGS	DEG_SCF_FBW7_1	698:704	Mutation altering degron motif	0.7694
p.P568L	DO220900	MELA	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation rewiring degron network	0.3056
p.S569Y	DO233295	NACA	ICGC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.712
p.R751M	SIDM02026	Colorectal Carcinoma	GDSC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.3056
p.R571T	SIDM00040	Gastric Carcinoma	GDSC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6765
p.R571T	SIDM00282	Colorectal Carcinoma	GDSC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6765
p.R571T	TMK-1	stomach	COSMIC	SVRSLAVPTI	DEG_COP1_1	569:578	Mutation altering degron motif	0.6765
p.R759H	SIDM00518	Mesothelioma	GDSC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.0833
p.R759H	SIDM00694	Other Solid Cancers	GDSC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.0833
p.T758A	SIDM00870	Breast Carcinoma	GDSC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.1111
p.T758A	ACH-000725	Breast Cancer	CCLE	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.1111
p.T758A	HCC202	breast	COSMIC	SRSDLPVIQ	DEG_APCC_DBOX_1	742:750	Mutation rewiring degron network	0.1111
p.P391S	ACH-000773	Lymphoma	CCLE	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation altering degron motif	0.5641
p.D381G	ACH-001484	Leukemia	CCLE	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation rewiring degron network	0.1667
p.D381G	ACH-001485	Leukemia	CCLE	TQEDPEQVPEL	DEG_COP1_1	387:397	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UTP14C

UniProt ID: Q5TAP6

Entrez ID: 9724

Protein name: U3 small nucleolar RNA-associated protein 14 homolog C

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for UTP14C in