DegronMD

Uniprot ID: Q5TAP6

Source protein: U3 small nucleolar RNA-associated protein 14 homolog C

Source gene: UTP14C

Class: DEG_APCC_DBOX_1

Location: 742:750

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9489

ASA_SCORE: 93.5667

COIL: 0.7792

CONS_SCORE: 0.1905

DSS_SCORE: 0.5795

HELIX: 0.192

FCONS_SCORE: 0.7485

RIG_SCORE: 0.7084

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G737D	TCGA-B5-A3F9	UCEC	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	0.1944
p.G737D	DO52401	UCEC	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.1944
p.R759C	TCGA-B5-A3FC	UCEC	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	0.0833
p.R759C	TCGA-R5-A7ZI	STAD	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	0.0833
p.R759C	DO233089	GACA	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.0833
p.R759C	DO222342	STAD	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.0833
p.R759C	DO41871	UCEC	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.0833
p.D735Y	TCGA-B6-A0I8	BRCA	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	0.1389
p.D735Y	DO2149	BRCA	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.1389
p.Q750R	TCGA-DF-A2KU	UCEC	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	0.6218
p.Q750R	DO223286	UCEC	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.6218
p.S742L	TCGA-FD-A3SS	BLCA	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	0.7667
p.S742L	DO737	BLCA	ICGC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.7667
p.V736L	TCGA-V4-A9EI	UVM	TCGA	SRSDLPVIQ	DEG_APCC_DBOX_1	0.1667
p.R751M	SIDM02026	Colorectal Carcinoma	GDSC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.3056
p.R759H	SIDM00518	Mesothelioma	GDSC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.0833
p.R759H	SIDM00694	Other Solid Cancers	GDSC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.0833
p.T758A	SIDM00870	Breast Carcinoma	GDSC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.1111
p.T758A	ACH-000725	Breast Cancer	CCLE	SRSDLPVIQ	DEG_APCC_DBOX_1	0.1111
p.T758A	HCC202	breast	COSMIC	SRSDLPVIQ	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TAP6	U3 small nucleolar RNA-associated protein 14 homolog C	DEG_APCC_DBOX_1	742:750	SRSDLPVIQ	APC,CDC20,FZR1	0.9489	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons