DegronMD

Uniprot ID: Q5TAP6

Source protein: U3 small nucleolar RNA-associated protein 14 homolog C

Source gene: UTP14C

Class: DEG_COP1_1

Location: 569:578

E3 ligase: COP1

DEGRON score: 0.8174

ASA_SCORE: 78.17

COIL: 0.7897

CONS_SCORE: 0.2077

DSS_SCORE: 0.4332

HELIX: 0.1557

FCONS_SCORE: 0.8556

RIG_SCORE: 0.7509

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P576S	TCGA-06-5416	GBM	TCGA	SVRSLAVPTI	DEG_COP1_1	0.6752
p.P576S	DO233759	GACA	ICGC	SVRSLAVPTI	DEG_COP1_1	0.6752
p.P576S	DO10880	GBM	ICGC	SVRSLAVPTI	DEG_COP1_1	0.6752
p.P576S	DO233295	NACA	ICGC	SVRSLAVPTI	DEG_COP1_1	0.6752
p.S569F	TCGA-18-3409	LUSC	TCGA	SVRSLAVPTI	DEG_COP1_1	0.7982
p.S569F	DO26444	LUSC	ICGC	SVRSLAVPTI	DEG_COP1_1	0.7982
p.E581Q	TCGA-21-1077	LUSC	TCGA	SVRSLAVPTI	DEG_COP1_1	0.25
p.E581Q	DO26725	LUSC	ICGC	SVRSLAVPTI	DEG_COP1_1	0.25
p.N561H	TCGA-A5-A1OF	UCEC	TCGA	SVRSLAVPTI	DEG_COP1_1	0.1111
p.N561H	DO42568	UCEC	ICGC	SVRSLAVPTI	DEG_COP1_1	0.1111
p.S572Y	TCGA-AG-A002	READ	TCGA	SVRSLAVPTI	DEG_COP1_1	0.712
p.S572Y	TCGA-BK-A6W3	UCEC	TCGA	SVRSLAVPTI	DEG_COP1_1	0.712
p.S572Y	DO50076	UCEC	ICGC	SVRSLAVPTI	DEG_COP1_1	0.712
p.S572Y	SIDM01611	Endometrial Carcinoma	GDSC	SVRSLAVPTI	DEG_COP1_1	0.712
p.S572Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	SVRSLAVPTI	DEG_COP1_1	0.712
p.A574T	TCGA-BR-8363	STAD	TCGA	SVRSLAVPTI	DEG_COP1_1	0.6028
p.A574T	DO232761	PBCA	ICGC	SVRSLAVPTI	DEG_COP1_1	0.6028
p.A574T	DO47837	STAD	ICGC	SVRSLAVPTI	DEG_COP1_1	0.6028
p.V570M	TCGA-CK-5916	COAD	TCGA	SVRSLAVPTI	DEG_COP1_1	0.6097
p.V570M	DO8786	COAD	ICGC	SVRSLAVPTI	DEG_COP1_1	0.6097
p.V570L	TCGA-L9-A7SV	LUAD	TCGA	SVRSLAVPTI	DEG_COP1_1	0.5654
p.V570L	DO49875	LUAD	ICGC	SVRSLAVPTI	DEG_COP1_1	0.5654
p.D584H	TCGA-Q1-A73O	CESC	TCGA	SVRSLAVPTI	DEG_COP1_1	0.1667
p.D584H	DO51612	CESC	ICGC	SVRSLAVPTI	DEG_COP1_1	0.1667
p.F562L	DO222884	COCA	ICGC	SVRSLAVPTI	DEG_COP1_1	0.1389
p.R588I	DO229008	LICA	ICGC	SVRSLAVPTI	DEG_COP1_1	0.0556
p.P568L	DO220900	MELA	ICGC	SVRSLAVPTI	DEG_COP1_1	0.3056
p.S569Y	DO233295	NACA	ICGC	SVRSLAVPTI	DEG_COP1_1	0.712
p.R571T	SIDM00040	Gastric Carcinoma	GDSC	SVRSLAVPTI	DEG_COP1_1	0.6765
p.R571T	SIDM00282	Colorectal Carcinoma	GDSC	SVRSLAVPTI	DEG_COP1_1	0.6765
p.R571T	TMK-1	stomach	COSMIC	SVRSLAVPTI	DEG_COP1_1	0.6765

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SVRSLAVPTI

Degron related mutations and impact score

Drug responses associated with UTP14C mutations

All proteins holding degron of SVRSLAVPTI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TAP6	U3 small nucleolar RNA-associated protein 14 homolog C	DEG_COP1_1	569:578	SVRSLAVPTI	COP1	0.8174	More...