DegronMD

Uniprot ID: Q5TAP6

Source protein: U3 small nucleolar RNA-associated protein 14 homolog C

Source gene: UTP14C

Class: DEG_COP1_1

Location: 387:397

E3 ligase: COP1

DEGRON score: 0.976

ASA_SCORE: 91.5455

COIL: 0.488

CONS_SCORE: 0.3367

DSS_SCORE: 0.7187

HELIX: 0.4984

FCONS_SCORE: 1.2449

RIG_SCORE: 0.6846

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S380N	TCGA-CU-A0YN	BLCA	TCGA	TQEDPEQVPEL	DEG_COP1_1	0.1389
p.S380N	DO488	BLCA	ICGC	TQEDPEQVPEL	DEG_COP1_1	0.1389
p.P391T	TCGA-DA-A1I2	SKCM	TCGA	TQEDPEQVPEL	DEG_COP1_1	0.5919
p.P391T	DO37758	SKCM	ICGC	TQEDPEQVPEL	DEG_COP1_1	0.5919
p.S403F	TCGA-FW-A3R5	SKCM	TCGA	TQEDPEQVPEL	DEG_COP1_1	0.1667
p.S403F	DO37406	SKCM	ICGC	TQEDPEQVPEL	DEG_COP1_1	0.1667
p.S405R	DO222397	BTCA	ICGC	TQEDPEQVPEL	DEG_COP1_1	0.1111
p.V394M	DO222623	BTCA	ICGC	TQEDPEQVPEL	DEG_COP1_1	0.7208
p.E384D	DO229019	LICA	ICGC	TQEDPEQVPEL	DEG_COP1_1	0.25
p.P391S	ACH-000773	Lymphoma	CCLE	TQEDPEQVPEL	DEG_COP1_1	0.5641
p.D381G	ACH-001484	Leukemia	CCLE	TQEDPEQVPEL	DEG_COP1_1	0.1667
p.D381G	ACH-001485	Leukemia	CCLE	TQEDPEQVPEL	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TAP6	U3 small nucleolar RNA-associated protein 14 homolog C	DEG_COP1_1	387:397	TQEDPEQVPEL	COP1	0.976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons