DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_SCF_FBW7_1

Location: 127:134

E3 ligase: FBXW7

DEGRON score: 0.9312

ASA_SCORE: 90.9875

COIL: 0.9569

CONS_SCORE: 0.3761

DSS_SCORE: 0.2885

HELIX: 0.0168

FCONS_SCORE: 0.8626

RIG_SCORE: 0.6461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P136A	TCGA-63-A5MM	LUSC	TCGA	LKGTPSSS	DEG_SCF_FBW7_1	0.2778
p.P136A	DO219153	LUSC	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.2778
p.I123T	TCGA-ZF-AA4R	BLCA	TCGA	LKGTPSSS	DEG_SCF_FBW7_1	0.2222
p.I123T	DO219083	BLCA	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.2222
p.Q133E	DO229057	LICA	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.6744
p.L139V	DO48723	LIRI	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.1944
p.E141D	DO26854	LUSC	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.1389
p.P136S	DO222731	MELA	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.2778
p.I128M	DO31789	OV	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.7618
p.I128T	DO38259	STAD	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.7078
p.A126V	DO41903	UCEC	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.3056
p.A135V	DO230449	UTCA	ICGC	LKGTPSSS	DEG_SCF_FBW7_1	0.3056
p.P131L	SIDM00857	Melanoma	GDSC	LKGTPSSS	DEG_SCF_FBW7_1	0.7582
p.P131L	ACH-000572	Skin Cancer	CCLE	LKGTPSSS	DEG_SCF_FBW7_1	0.7582
p.P131L	G-361	skin	COSMIC	LKGTPSSS	DEG_SCF_FBW7_1	0.7582
p.L142R	SIDM00900	Non-Cancerous	GDSC	LKGTPSSS	DEG_SCF_FBW7_1	0.1111
p.Q136H	ACH-000945	Lung Cancer	CCLE	LKGTPSSS	DEG_SCF_FBW7_1	0.2778
p.Q136H	NCI-H650	lung	COSMIC	LKGTPSSS	DEG_SCF_FBW7_1	0.2778
p.G124E	ACH-000995	Leukemia	CCLE	LKGTPSSS	DEG_SCF_FBW7_1	0.25
p.G124E	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LKGTPSSS	DEG_SCF_FBW7_1	0.25
p.N129S	ML-1	thyroid	COSMIC	LKGTPSSS	DEG_SCF_FBW7_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_SCF_FBW7_1	127:134	LKGTPSSS	FBXW7	0.9312	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons