DegronMD

Uniprot ID: O43593

Source protein: Lysine-specific demethylase hairless

Source gene: HR

Class: DEG_SCF_FBW7_2

Location: 8:15

E3 ligase: FBXW7

DEGRON score: 0.8799

ASA_SCORE: 72.2625

COIL: 0.7724

CONS_SCORE: 0.3836

DSS_SCORE: 0.7048

HELIX: 0.1243

FCONS_SCORE: 0.7967

RIG_SCORE: 0.6789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E15D	TCGA-AJ-A3EK	UCEC	TCGA	LKGTPTWE	DEG_SCF_FBW7_2	0.6758
p.E15D	TCGA-S9-A7QX	LGG	TCGA	LKGTPTWE	DEG_SCF_FBW7_2	0.6758
p.E15D	DO50214	LGG	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	0.6758
p.E15D	DO41584	UCEC	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	0.6758
p.P5L	TCGA-CK-4951	COAD	TCGA	LKGTPTWE	DEG_SCF_FBW7_2	0.25
p.P5L	DO10582	COAD	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	0.25
p.P12T	TCGA-EI-6917	READ	TCGA	LKGTPTWE	DEG_SCF_FBW7_2	0.7031
p.P12T	DO36881	READ	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	0.7031
p.T13N	DO229037	LICA	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	0.5944
p.E2K	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	0.1667
p.E2K	ACH-000521	Lung Cancer	CCLE	LKGTPTWE	DEG_SCF_FBW7_2	0.1667
p.E2K	NCI-H2030	lung	COSMIC	LKGTPTWE	DEG_SCF_FBW7_2	0.1667
p.V24M	SIDM00343	Glioblastoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	0.0833
p.V24M	LN-405	central_nervous_system	COSMIC	LKGTPTWE	DEG_SCF_FBW7_2	0.0833
p.N21K	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	0.1667
p.N21K	ACH-000666	Lung Cancer	CCLE	LKGTPTWE	DEG_SCF_FBW7_2	0.1667
p.N21K	NCI-H1355	lung	COSMIC	LKGTPTWE	DEG_SCF_FBW7_2	0.1667
p.T13A	SIDM00941	Kidney Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	0.6028
p.T13A	SIDM01121	Small Cell Lung Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	0.6028
p.T13A	SIDM00218	Thyroid Gland Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	0.6028
p.T13A	SIDM01590	Breast Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43593	Lysine-specific demethylase hairless	DEG_SCF_FBW7_2	8:15	LKGTPTWE	FBXW7	0.8799	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons