DegronMD - O43593(HR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H727Q	TCGA-A5-A0GQ	UCEC	TCGA	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation rewiring degron network	0.1667
p.H727Q	DO41404	UCEC	ICGC	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation rewiring degron network	0.1667
p.E15D	TCGA-AJ-A3EK	UCEC	TCGA	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.6758
p.E15D	TCGA-S9-A7QX	LGG	TCGA	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.6758
p.E15D	DO50214	LGG	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.6758
p.E15D	DO41584	UCEC	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.6758
p.Q712H	TCGA-AX-A2HC	UCEC	TCGA	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation rewiring degron network	0.25
p.Q712H	DO41572	UCEC	ICGC	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation rewiring degron network	0.25
p.P5L	TCGA-CK-4951	COAD	TCGA	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.25
p.P5L	DO10582	COAD	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.25
p.P12T	TCGA-EI-6917	READ	TCGA	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.7031
p.P12T	DO36881	READ	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.7031
p.S721F	TCGA-GN-A266	SKCM	TCGA	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation altering degron motif	0.7982
p.S721F	DO37432	SKCM	ICGC	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation altering degron motif	0.7982
p.G724S	TCGA-XK-AAIW	PRAD	TCGA	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation rewiring degron network	0.25
p.G724S	DO51407	PRAD	ICGC	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation rewiring degron network	0.25
p.T729N	DO229032	LICA	ICGC	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation rewiring degron network	0.1111
p.P715T	DO229035	LICA	ICGC	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation altering degron motif	0.7031
p.T714K	DO229038	LICA	ICGC	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation rewiring degron network	0.3056
p.T13N	DO229037	LICA	ICGC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.5944
p.E2K	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.1667
p.E2K	ACH-000521	Lung Cancer	CCLE	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.1667
p.E2K	NCI-H2030	lung	COSMIC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.1667
p.P716Q	SIDM00660	Colorectal Carcinoma	GDSC	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation altering degron motif	0.5924
p.P716Q	ACH-000985	Colon/Colorectal Cancer	CCLE	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation altering degron motif	0.5924
p.P716Q	LS-411N	large intestine	COSMIC	PPTPQPS	DEG_SCF_FBW7_1	715:721	Mutation altering degron motif	0.5924
p.V24M	SIDM00343	Glioblastoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.0833
p.V24M	LN-405	central nervous system	COSMIC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.0833
p.N21K	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.1667
p.N21K	ACH-000666	Lung Cancer	CCLE	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.1667
p.N21K	NCI-H1355	lung	COSMIC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation rewiring degron network	0.1667
p.T13A	SIDM00941	Kidney Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.6028
p.T13A	SIDM01121	Small Cell Lung Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.6028
p.T13A	SIDM00218	Thyroid Gland Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.6028
p.T13A	SIDM01590	Breast Carcinoma	GDSC	LKGTPTWE	DEG_SCF_FBW7_2	8:15	Mutation altering degron motif	0.6028

Kaplan plot for HR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HR

UniProt ID: O43593

Entrez ID: 55806

Protein name: Lysine-specific demethylase hairless (EC 1.14.11.65) ([histone H3]-dimethyl-L-lysine(9) demethylase hairless)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HR in