DegronMD

Uniprot ID: O43593

Source protein: Lysine-specific demethylase hairless

Source gene: HR

Class: DEG_SCF_FBW7_1

Location: 715:721

E3 ligase: FBXW7

DEGRON score: 0.6755

ASA_SCORE: 84.2714

COIL: 0.9346

CONS_SCORE: 0.4458

DSS_SCORE: 0.8259

HELIX: 0.031

FCONS_SCORE: 0.9176

RIG_SCORE: 0.5477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H727Q	TCGA-A5-A0GQ	UCEC	TCGA	PPTPQPS	DEG_SCF_FBW7_1	0.1667
p.H727Q	DO41404	UCEC	ICGC	PPTPQPS	DEG_SCF_FBW7_1	0.1667
p.Q712H	TCGA-AX-A2HC	UCEC	TCGA	PPTPQPS	DEG_SCF_FBW7_1	0.25
p.Q712H	DO41572	UCEC	ICGC	PPTPQPS	DEG_SCF_FBW7_1	0.25
p.S721F	TCGA-GN-A266	SKCM	TCGA	PPTPQPS	DEG_SCF_FBW7_1	0.7982
p.S721F	DO37432	SKCM	ICGC	PPTPQPS	DEG_SCF_FBW7_1	0.7982
p.G724S	TCGA-XK-AAIW	PRAD	TCGA	PPTPQPS	DEG_SCF_FBW7_1	0.25
p.G724S	DO51407	PRAD	ICGC	PPTPQPS	DEG_SCF_FBW7_1	0.25
p.T729N	DO229032	LICA	ICGC	PPTPQPS	DEG_SCF_FBW7_1	0.1111
p.P715T	DO229035	LICA	ICGC	PPTPQPS	DEG_SCF_FBW7_1	0.7031
p.T714K	DO229038	LICA	ICGC	PPTPQPS	DEG_SCF_FBW7_1	0.3056
p.P716Q	SIDM00660	Colorectal Carcinoma	GDSC	PPTPQPS	DEG_SCF_FBW7_1	0.5924
p.P716Q	ACH-000985	Colon/Colorectal Cancer	CCLE	PPTPQPS	DEG_SCF_FBW7_1	0.5924
p.P716Q	LS-411N	large_intestine	COSMIC	PPTPQPS	DEG_SCF_FBW7_1	0.5924

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43593	Lysine-specific demethylase hairless	DEG_SCF_FBW7_1	715:721	PPTPQPS	FBXW7	0.6755	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons