DegronMD

Uniprot ID: Q53T59

Source protein: HCLS1-binding protein 3

Source gene: HS1BP3

Class: LIG_APCC_ABBA_1

Location: 263:268

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9327

ASA_SCORE: 67.8833

COIL: 0.6707

CONS_SCORE: 0.4503

DSS_SCORE: 0.4863

HELIX: 0.2102

FCONS_SCORE: 1.1801

RIG_SCORE: 0.7829

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D270A	TCGA-BG-A222	UCEC	TCGA	LKLFDD	LIG_APCC_ABBA_1	0.2778
p.D270A	DO42977	UCEC	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.2778
p.P253L	TCGA-DA-A95X	SKCM	TCGA	LKLFDD	LIG_APCC_ABBA_1	0.0556
p.P253L	DO229177	LMS	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.0556
p.P253L	DO219480	SKCM	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.0556
p.L271I	TCGA-DF-A2KU	UCEC	TCGA	LKLFDD	LIG_APCC_ABBA_1	0.25
p.L271I	DO223286	UCEC	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.S254L	DO229389	BTCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.5278
p.S254L	SIDM00444	Esophageal Carcinoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	0.5278
p.S254L	OACM5-1	oesophagus	COSMIC	LKLFDD	LIG_APCC_ABBA_1	0.5278
p.V260M	DO229010	COCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.V260M	DO229013	COCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.V260M	DO229003	COCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.V260M	DO229005	COCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.V260M	DO223150	ESCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.V260M	DO229353	LAML	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.V260M	DO228941	LICA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.V260M	DO229047	LICA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.V260M	DO230529	LUSC	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.25
p.P262S	DO233267	GACA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0.3056
p.DP261DS	DO222775	MELA	ICGC	LKLFDD	LIG_APCC_ABBA_1	0
p.G273R	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	0.1944
p.G273R	SIDM00694	Other Solid Cancers	GDSC	LKLFDD	LIG_APCC_ABBA_1	0.1944
p.G273R	SIDM00863	Burkitt's Lymphoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	0.1944
p.G273R	SIDM01173	Rhabdomyosarcoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	0.1944
p.G273R	SIDM00785	Acute Myeloid Leukemia	GDSC	LKLFDD	LIG_APCC_ABBA_1	0.1944
p.G273R	SIDM01318	Hepatocellular Carcinoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	0.1944
p.G273R	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LKLFDD	LIG_APCC_ABBA_1	0.1944
p.G273R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LKLFDD

Degron related mutations and impact score

Drug responses associated with HS1BP3 mutations

All proteins holding degron of LKLFDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53T59	HCLS1-binding protein 3	LIG_APCC_ABBA_1	263:268	LKLFDD	APC,CDC20,FZR1	0.9327	More...