DegronMD - Q53T59(HS1BP3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E288V	TCGA-A3-3319	KIRC	TCGA	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.2222
p.R227W	TCGA-AA-A01R	COAD	TCGA	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation altering degron motif	0.8634
p.R227W	DO7934	COAD	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation altering degron motif	0.8634
p.P284L	TCGA-AP-A059	UCEC	TCGA	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1111
p.P284L	TCGA-B5-A11F	UCEC	TCGA	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1111
p.P284L	TCGA-VQ-A91D	STAD	TCGA	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1111
p.P284L	DO51783	STAD	ICGC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1111
p.P284L	DO43618	UCEC	ICGC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1111
p.P284L	DO41361	UCEC	ICGC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1111
p.D270A	TCGA-BG-A222	UCEC	TCGA	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.2778
p.D270A	DO42977	UCEC	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.2778
p.P253L	TCGA-DA-A95X	SKCM	TCGA	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.0556
p.P253L	DO229177	LMS	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.0556
p.P253L	DO219480	SKCM	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.0556
p.L271I	TCGA-DF-A2KU	UCEC	TCGA	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.L271I	DO223286	UCEC	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.G291W	TCGA-FV-A2QR	LIHC	TCGA	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.3056
p.G291W	DO22837	LIHC	ICGC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.3056
p.E234D	TCGA-G4-6588	COAD	TCGA	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.3056
p.E234D	TCGA-G4-6588	COAD	TCGA	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.3056
p.E234D	DO10140	COAD	ICGC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.3056
p.E234D	DO10140	COAD	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.3056
p.K303N	TCGA-HU-A4GQ	STAD	TCGA	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation substituting flanking lysine	0.2778
p.K303N	DO47767	STAD	ICGC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation substituting flanking lysine	0.2778
p.E239K	TCGA-UC-A7PG	CESC	TCGA	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.1667
p.E239K	TCGA-UC-A7PG	CESC	TCGA	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.1667
p.E239K	DO51615	CESC	ICGC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.1667
p.E239K	DO51615	CESC	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.1667
p.S254L	DO229389	BTCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation blocking phosphorylation signal	0.5278
p.S254L	SIDM00444	Esophageal Carcinoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation blocking phosphorylation signal	0.5278
p.S254L	OACM5-1	oesophagus	COSMIC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation blocking phosphorylation signal	0.5278
p.V260M	DO229010	COCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.V260M	DO229013	COCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.V260M	DO229003	COCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.V260M	DO229005	COCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.V260M	DO223150	ESCA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.V260M	DO229353	LAML	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.V260M	DO228941	LICA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.V260M	DO229047	LICA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.V260M	DO230529	LUSC	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.25
p.P262S	DO233267	GACA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.3056
p.A219V	DO233935	GACA	ICGC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.0833
p.A219V	DO233935	GACA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.1111
p.D236E	DO229038	LICA	ICGC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.25
p.D236E	DO229038	LICA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.25
p.A301V	DO50971	LICA	ICGC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.2222
p.A301V	DO220859	MELA	ICGC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.2222
p.DP261DS	DO222775	MELA	ICGC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0
p.D236H	DO233293	NACA	ICGC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.25
p.D236H	DO233293	NACA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.25
p.G240R	DO233293	NACA	ICGC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.1389
p.G240R	DO233293	NACA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.1389
p.P224S	DO229459	SKCA	ICGC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.2222
p.P224S	DO229459	SKCA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.25
p.R307G	DO229213	THCA	ICGC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.0556
p.G273R	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1944
p.G273R	SIDM00694	Other Solid Cancers	GDSC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1944
p.G273R	SIDM00863	Burkitt's Lymphoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1944
p.G273R	SIDM01173	Rhabdomyosarcoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1944
p.G273R	SIDM00785	Acute Myeloid Leukemia	GDSC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1944
p.G273R	SIDM01318	Hepatocellular Carcinoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1944
p.G273R	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1944
p.G273R	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LKLFDD	LIG_APCC_ABBA_1	263:268	Mutation rewiring degron network	0.1944
p.P224L	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.2222
p.P224L	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.25
p.P224L	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.2222
p.P224L	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.25
p.P224L	SIDM00910	Neuroblastoma	GDSC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.2222
p.P224L	SIDM00910	Neuroblastoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.25
p.P224L	SIDM01059	Melanoma	GDSC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.2222
p.P224L	SIDM01059	Melanoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.25
p.P224L	SIDM01706	Hodgkin's Lymphoma	GDSC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.2222
p.P224L	SIDM01706	Hodgkin's Lymphoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.25
p.A285T	SIDM00024	Non-Cancerous	GDSC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1389
p.A285T	ACH-001495	Endometrial/Uterine Cancer	CCLE	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1389
p.L296H	SIDM00276	Biliary Tract Carcinoma	GDSC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation altering degron motif	0.6202
p.L296H	ACH-001858	Bile Duct Cancer	CCLE	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation altering degron motif	0.6202
p.L296H	ACH-002237	Bile Duct Cancer	CCLE	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation altering degron motif	0.6202
p.L296H	ETK-1	biliary tract	COSMIC	PTPSLS	DEG_SCF_FBW7_1	292:297	Mutation altering degron motif	0.6202
p.S225L	SIDM00312	Plasma Cell Myeloma	GDSC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.25
p.S225L	SIDM00312	Plasma Cell Myeloma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.2778
p.S225L	SIDM01470	Acute Myeloid Leukemia	GDSC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.25
p.S225L	SIDM01470	Acute Myeloid Leukemia	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.2778
p.S225L	ACH-000183	Myeloma	CCLE	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.25
p.S225L	ACH-000183	Myeloma	CCLE	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.2778
p.S225L	ACH-000387	Leukemia	CCLE	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.25
p.S225L	ACH-000387	Leukemia	CCLE	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.2778
p.S225L	L-363	haematopoietic and lymphoid tissue	COSMIC	LTIFDE	LIG_APCC_ABBA_1	228:233	Mutation rewiring degron network	0.25
p.S225L	L-363	haematopoietic and lymphoid tissue	COSMIC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	227:233	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HS1BP3

UniProt ID: Q53T59

Entrez ID: 64342

Protein name: HCLS1-binding protein 3 (HS1-binding protein 3) (HSP1BP-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HS1BP3 in