DegronMD

Uniprot ID: Q53T59

Source protein: HCLS1-binding protein 3

Source gene: HS1BP3

Class: LIG_APCC_ABBAyCdc20_2

Location: 227:233

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7373

ASA_SCORE: 83.3286

COIL: 0.7133

CONS_SCORE: 0.4227

DSS_SCORE: 0.5552

HELIX: 0.1919

FCONS_SCORE: 0.9712

RIG_SCORE: 0.7489

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R227W	TCGA-AA-A01R	COAD	TCGA	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.8634
p.R227W	DO7934	COAD	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.8634
p.E234D	TCGA-G4-6588	COAD	TCGA	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E234D	DO10140	COAD	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E239K	TCGA-UC-A7PG	CESC	TCGA	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E239K	DO51615	CESC	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A219V	DO233935	GACA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D236E	DO229038	LICA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.D236H	DO233293	NACA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.G240R	DO233293	NACA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P224S	DO229459	SKCA	ICGC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.P224L	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.P224L	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.P224L	SIDM00910	Neuroblastoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.P224L	SIDM01059	Melanoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.P224L	SIDM01706	Hodgkin's Lymphoma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.25
p.S225L	SIDM00312	Plasma Cell Myeloma	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S225L	SIDM01470	Acute Myeloid Leukemia	GDSC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S225L	ACH-000183	Myeloma	CCLE	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S225L	ACH-000387	Leukemia	CCLE	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S225L	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	RLTIFDE	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53T59	HCLS1-binding protein 3	LIG_APCC_ABBAyCdc20_2	227:233	RLTIFDE	APC,CDC20,FZR1	0.7373	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons