DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PTPSLS
Uniprot ID:
Q53T59
Source protein:
HCLS1-binding protein 3
Source gene:
HS1BP3
Class:
DEG_SCF_FBW7_1
Location:
292:297
E3 ligase:
FBXW7
DEGRON score:
0.9942
ASA_SCORE:
76.3333
COIL:
0.8812
CONS_SCORE:
0.2929
DSS_SCORE:
0.5847
HELIX:
0.0753
FCONS_SCORE:
0.6448
RIG_SCORE:
0.6008
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E288V
TCGA-A3-3319
KIRC
TCGA
PTPSLS
DEG_SCF_FBW7_1
0.2222
p.P284L
TCGA-AP-A059
UCEC
TCGA
PTPSLS
DEG_SCF_FBW7_1
0.1111
p.P284L
TCGA-B5-A11F
UCEC
TCGA
PTPSLS
DEG_SCF_FBW7_1
0.1111
p.P284L
TCGA-VQ-A91D
STAD
TCGA
PTPSLS
DEG_SCF_FBW7_1
0.1111
p.P284L
DO51783
STAD
ICGC
PTPSLS
DEG_SCF_FBW7_1
0.1111
p.P284L
DO43618
UCEC
ICGC
PTPSLS
DEG_SCF_FBW7_1
0.1111
p.P284L
DO41361
UCEC
ICGC
PTPSLS
DEG_SCF_FBW7_1
0.1111
p.G291W
TCGA-FV-A2QR
LIHC
TCGA
PTPSLS
DEG_SCF_FBW7_1
0.3056
p.G291W
DO22837
LIHC
ICGC
PTPSLS
DEG_SCF_FBW7_1
0.3056
p.K303N
TCGA-HU-A4GQ
STAD
TCGA
PTPSLS
DEG_SCF_FBW7_1
0.2778
p.K303N
DO47767
STAD
ICGC
PTPSLS
DEG_SCF_FBW7_1
0.2778
p.A301V
DO50971
LICA
ICGC
PTPSLS
DEG_SCF_FBW7_1
0.2222
p.A301V
DO220859
MELA
ICGC
PTPSLS
DEG_SCF_FBW7_1
0.2222
p.R307G
DO229213
THCA
ICGC
PTPSLS
DEG_SCF_FBW7_1
0.0556
p.A285T
SIDM00024
Non-Cancerous
GDSC
PTPSLS
DEG_SCF_FBW7_1
0.1389
p.A285T
ACH-001495
Endometrial/Uterine Cancer
CCLE
PTPSLS
DEG_SCF_FBW7_1
0.1389
p.L296H
SIDM00276
Biliary Tract Carcinoma
GDSC
PTPSLS
DEG_SCF_FBW7_1
0.6202
p.L296H
ACH-001858
Bile Duct Cancer
CCLE
PTPSLS
DEG_SCF_FBW7_1
0.6202
p.L296H
ACH-002237
Bile Duct Cancer
CCLE
PTPSLS
DEG_SCF_FBW7_1
0.6202
p.L296H
ETK-1
biliary_tract
COSMIC
PTPSLS
DEG_SCF_FBW7_1
0.6202
Drug responses associated with HS1BP3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTPSLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q53T59
HCLS1-binding protein 3
DEG_SCF_FBW7_1
292:297
PTPSLS
FBXW7
0.9942
More...