DegronMD

Uniprot ID: Q53T59

Source protein: HCLS1-binding protein 3

Source gene: HS1BP3

Class: DEG_SCF_FBW7_1

Location: 292:297

E3 ligase: FBXW7

DEGRON score: 0.9942

ASA_SCORE: 76.3333

COIL: 0.8812

CONS_SCORE: 0.2929

DSS_SCORE: 0.5847

HELIX: 0.0753

FCONS_SCORE: 0.6448

RIG_SCORE: 0.6008

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L296H	SIDM00276	Biliary Tract Carcinoma	GDSC	PTPSLS	DEG_SCF_FBW7_1	0.6202
p.L296H	ACH-001858	Bile Duct Cancer	CCLE	PTPSLS	DEG_SCF_FBW7_1	0.6202
p.L296H	ACH-002237	Bile Duct Cancer	CCLE	PTPSLS	DEG_SCF_FBW7_1	0.6202
p.L296H	ETK-1	biliary_tract	COSMIC	PTPSLS	DEG_SCF_FBW7_1	0.6202
p.G291W	TCGA-FV-A2QR	LIHC	TCGA	PTPSLS	DEG_SCF_FBW7_1	0.3056
p.G291W	DO22837	LIHC	ICGC	PTPSLS	DEG_SCF_FBW7_1	0.3056
p.K303N	TCGA-HU-A4GQ	STAD	TCGA	PTPSLS	DEG_SCF_FBW7_1	0.2778
p.K303N	DO47767	STAD	ICGC	PTPSLS	DEG_SCF_FBW7_1	0.2778
p.E288V	TCGA-A3-3319	KIRC	TCGA	PTPSLS	DEG_SCF_FBW7_1	0.2222
p.A301V	DO50971	LICA	ICGC	PTPSLS	DEG_SCF_FBW7_1	0.2222
p.A301V	DO220859	MELA	ICGC	PTPSLS	DEG_SCF_FBW7_1	0.2222
p.A285T	SIDM00024	Non-Cancerous	GDSC	PTPSLS	DEG_SCF_FBW7_1	0.1389
p.A285T	ACH-001495	Endometrial/Uterine Cancer	CCLE	PTPSLS	DEG_SCF_FBW7_1	0.1389
p.P284L	TCGA-AP-A059	UCEC	TCGA	PTPSLS	DEG_SCF_FBW7_1	0.1111
p.P284L	TCGA-B5-A11F	UCEC	TCGA	PTPSLS	DEG_SCF_FBW7_1	0.1111
p.P284L	TCGA-VQ-A91D	STAD	TCGA	PTPSLS	DEG_SCF_FBW7_1	0.1111
p.P284L	DO51783	STAD	ICGC	PTPSLS	DEG_SCF_FBW7_1	0.1111
p.P284L	DO43618	UCEC	ICGC	PTPSLS	DEG_SCF_FBW7_1	0.1111
p.P284L	DO41361	UCEC	ICGC	PTPSLS	DEG_SCF_FBW7_1	0.1111
p.R307G	DO229213	THCA	ICGC	PTPSLS	DEG_SCF_FBW7_1	0.0556

Showing 1 to 20 of 20 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53T59	HCLS1-binding protein 3	DEG_SCF_FBW7_1	292:297	PTPSLS	FBXW7	0.9942	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons