DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTIFDE
Uniprot ID:
Q53T59
Source protein:
HCLS1-binding protein 3
Source gene:
HS1BP3
Class:
LIG_APCC_ABBA_1
Location:
228:233
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.859
ASA_SCORE:
72.0667
COIL:
0.6912
CONS_SCORE:
0.4293
DSS_SCORE:
0.5658
HELIX:
0.2147
FCONS_SCORE:
0.9804
RIG_SCORE:
0.7607
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E234D
TCGA-G4-6588
COAD
TCGA
LTIFDE
LIG_APCC_ABBA_1
0.3056
p.E234D
DO10140
COAD
ICGC
LTIFDE
LIG_APCC_ABBA_1
0.3056
p.E239K
TCGA-UC-A7PG
CESC
TCGA
LTIFDE
LIG_APCC_ABBA_1
0.1667
p.E239K
DO51615
CESC
ICGC
LTIFDE
LIG_APCC_ABBA_1
0.1667
p.A219V
DO233935
GACA
ICGC
LTIFDE
LIG_APCC_ABBA_1
0.0833
p.D236E
DO229038
LICA
ICGC
LTIFDE
LIG_APCC_ABBA_1
0.25
p.D236H
DO233293
NACA
ICGC
LTIFDE
LIG_APCC_ABBA_1
0.25
p.G240R
DO233293
NACA
ICGC
LTIFDE
LIG_APCC_ABBA_1
0.1389
p.P224S
DO229459
SKCA
ICGC
LTIFDE
LIG_APCC_ABBA_1
0.2222
p.P224L
SIDM01251
T-Cell Non-Hodgkin's Lymphoma
GDSC
LTIFDE
LIG_APCC_ABBA_1
0.2222
p.P224L
SIDM00753
Squamous Cell Lung Carcinoma
GDSC
LTIFDE
LIG_APCC_ABBA_1
0.2222
p.P224L
SIDM00910
Neuroblastoma
GDSC
LTIFDE
LIG_APCC_ABBA_1
0.2222
p.P224L
SIDM01059
Melanoma
GDSC
LTIFDE
LIG_APCC_ABBA_1
0.2222
p.P224L
SIDM01706
Hodgkin's Lymphoma
GDSC
LTIFDE
LIG_APCC_ABBA_1
0.2222
p.S225L
SIDM00312
Plasma Cell Myeloma
GDSC
LTIFDE
LIG_APCC_ABBA_1
0.25
p.S225L
SIDM01470
Acute Myeloid Leukemia
GDSC
LTIFDE
LIG_APCC_ABBA_1
0.25
p.S225L
ACH-000183
Myeloma
CCLE
LTIFDE
LIG_APCC_ABBA_1
0.25
p.S225L
ACH-000387
Leukemia
CCLE
LTIFDE
LIG_APCC_ABBA_1
0.25
p.S225L
L-363
haematopoietic_and_lymphoid_tissue
COSMIC
LTIFDE
LIG_APCC_ABBA_1
0.25
Drug responses associated with HS1BP3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTIFDE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q53T59
HCLS1-binding protein 3
LIG_APCC_ABBA_1
228:233
LTIFDE
APC,CDC20,FZR1
0.859
More...