DegronMD

Uniprot ID: O00124

Source protein: UBX domain-containing protein 8

Source gene: UBXN8

Class: LIG_APCC_ABBA_1

Location: 103:108

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9592

ASA_SCORE: 103.2

COIL: 0.4122

CONS_SCORE: 0.5558

DSS_SCORE: 0.3993

HELIX: 0.587

FCONS_SCORE: 1.1426

RIG_SCORE: 0.7798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I99T	SIDM00346	Chronic Myelogenous Leukemia	GDSC	LKPHQE	LIG_APCC_ABBA_1	0.2222
p.S101L	HCC-44	lung	COSMIC	LKPHQE	LIG_APCC_ABBA_1	0.2778
p.S101L	CAL-62	thyroid	COSMIC	LKPHQE	LIG_APCC_ABBA_1	0.2778
p.L97F	SAT	upper_aerodigestive_tract	COSMIC	LKPHQE	LIG_APCC_ABBA_1	0.1667
p.L97F	JHOS-3	ovary	COSMIC	LKPHQE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00124	UBX domain-containing protein 8	LIG_APCC_ABBA_1	103:108	LKPHQE	APC,CDC20,FZR1	0.9592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons