DegronMD

Uniprot ID: Q6ZQQ6

Source protein: WD repeat-containing protein 87

Source gene: WDR87

Class: DEG_SCF_FBW7_1

Location: 2462:2468

E3 ligase: FBXW7

DEGRON score: 0.8742

ASA_SCORE: 99.4429

COIL: 0.7014

CONS_SCORE: 0.3244

DSS_SCORE: 0.3112

HELIX: 0.2809

FCONS_SCORE: 1.0121

RIG_SCORE: 0.7923

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2478D	TCGA-AJ-A3EL	UCEC	TCGA	LKTPFMS	DEG_SCF_FBW7_1	0.0556
p.K2463N	DO222762	COCA	ICGC	LKTPFMS	DEG_SCF_FBW7_1	0.5806
p.K2463N	ACH-001081	Colon/Colorectal Cancer	CCLE	LKTPFMS	DEG_SCF_FBW7_1	0.5806
p.K2463N	HCC2998	large_intestine	COSMIC	LKTPFMS	DEG_SCF_FBW7_1	0.5806
p.F2466L	DO23527	LIRI	ICGC	LKTPFMS	DEG_SCF_FBW7_1	0.587
p.E2477K	DO222875	MELA	ICGC	LKTPFMS	DEG_SCF_FBW7_1	0.0833
p.R2466S	DO43041	UCEC	ICGC	LKTPFMS	DEG_SCF_FBW7_1	0.7427
p.A2459S	DO41199	UCEC	ICGC	LKTPFMS	DEG_SCF_FBW7_1	0.25
p.D2461N	ACH-001099	Rhabdoid	CCLE	LKTPFMS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZQQ6	WD repeat-containing protein 87	DEG_SCF_FBW7_1	2462:2468	LKTPFMS	FBXW7	0.8742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons