DegronMD - Q6ZQQ6(WDR87)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E980D	TCGA-AA-3510	COAD	TCGA	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation rewiring degron network	0.1944
p.E980D	DO7783	COAD	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation rewiring degron network	0.1944
p.E980D	DO232761	PBCA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation rewiring degron network	0.1944
p.E2478D	TCGA-AJ-A3EL	UCEC	TCGA	LKTPFMS	DEG_SCF_FBW7_1	2462:2468	Mutation rewiring degron network	0.0556
p.M1002I	TCGA-AP-A1DK	UCEC	TCGA	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation rewiring degron network	0.0833
p.S985C	TCGA-LN-A9FP	ESCA	TCGA	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation altering degron motif	0.7541
p.A999T	DO1285	BRCA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation rewiring degron network	0.1667
p.Q994P	DO222454	BTCA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation rewiring degron network	0.3056
p.K2463N	DO222762	COCA	ICGC	LKTPFMS	DEG_SCF_FBW7_1	2462:2468	Mutation altering degron motif	0.5806
p.K2463N	ACH-001081	Colon/Colorectal Cancer	CCLE	LKTPFMS	DEG_SCF_FBW7_1	2462:2468	Mutation altering degron motif	0.5806
p.K2463N	HCC2998	large intestine	COSMIC	LKTPFMS	DEG_SCF_FBW7_1	2462:2468	Mutation altering degron motif	0.5806
p.E982K	DO223048	ESCA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation rewiring degron network	0.25
p.F2466L	DO23527	LIRI	ICGC	LKTPFMS	DEG_SCF_FBW7_1	2462:2468	Mutation altering degron motif	0.587
p.L987V	DO220851	MELA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation altering degron motif	0.6765
p.E2477K	DO222875	MELA	ICGC	LKTPFMS	DEG_SCF_FBW7_1	2462:2468	Mutation rewiring degron network	0.0833
p.R2466S	DO43041	UCEC	ICGC	LKTPFMS	DEG_SCF_FBW7_1	2462:2468	Mutation altering degron motif	0.7427
p.A2459S	DO41199	UCEC	ICGC	LKTPFMS	DEG_SCF_FBW7_1	2462:2468	Mutation rewiring degron network	0.25
p.I976F	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation rewiring degron network	0.0833
p.I976F	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation rewiring degron network	0.0833
p.L992P	ACH-000510	Lung Cancer	CCLE	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation altering degron motif	0.7582
p.L992P	NCI-H1299	lung	COSMIC	SRTSLLQLT	DEG_APCC_DBOX_1	985:993	Mutation altering degron motif	0.7582
p.D2461N	ACH-001099	Rhabdoid	CCLE	LKTPFMS	DEG_SCF_FBW7_1	2462:2468	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR87

UniProt ID: Q6ZQQ6

Entrez ID: 83889

Protein name: WD repeat-containing protein 87 (Testis development protein NYD-SP11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR87 in