DegronMD

Uniprot ID: Q6ZQQ6

Source protein: WD repeat-containing protein 87

Source gene: WDR87

Class: DEG_APCC_DBOX_1

Location: 985:993

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8645

ASA_SCORE: 66.1222

COIL: 0.12

CONS_SCORE: 0.4915

DSS_SCORE: 0.3238

HELIX: 0.8722

FCONS_SCORE: 1.0143

RIG_SCORE: 0.7843

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E980D	TCGA-AA-3510	COAD	TCGA	SRTSLLQLT	DEG_APCC_DBOX_1	0.1944
p.E980D	DO7783	COAD	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	0.1944
p.E980D	DO232761	PBCA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	0.1944
p.M1002I	TCGA-AP-A1DK	UCEC	TCGA	SRTSLLQLT	DEG_APCC_DBOX_1	0.0833
p.S985C	TCGA-LN-A9FP	ESCA	TCGA	SRTSLLQLT	DEG_APCC_DBOX_1	0.7541
p.A999T	DO1285	BRCA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	0.1667
p.Q994P	DO222454	BTCA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	0.3056
p.E982K	DO223048	ESCA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	0.25
p.L987V	DO220851	MELA	ICGC	SRTSLLQLT	DEG_APCC_DBOX_1	0.6765
p.I976F	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SRTSLLQLT	DEG_APCC_DBOX_1	0.0833
p.I976F	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SRTSLLQLT	DEG_APCC_DBOX_1	0.0833
p.L992P	ACH-000510	Lung Cancer	CCLE	SRTSLLQLT	DEG_APCC_DBOX_1	0.7582
p.L992P	NCI-H1299	lung	COSMIC	SRTSLLQLT	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZQQ6	WD repeat-containing protein 87	DEG_APCC_DBOX_1	985:993	SRTSLLQLT	APC,CDC20,FZR1	0.8645	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons