DegronMD

Uniprot ID: Q8NFW9

Source protein: Rab effector MyRIP

Source gene: MYRIP

Class: DEG_SCF_FBW7_2

Location: 305:311

E3 ligase: FBXW7

DEGRON score: 0.9855

ASA_SCORE: 97.6714

COIL: 0.8953

CONS_SCORE: 0.6064

DSS_SCORE: 0.6969

HELIX: 0.0641

FCONS_SCORE: 1.0993

RIG_SCORE: 0.6563

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E302D	TCGA-A5-A2K5	UCEC	TCGA	LKTPPVE	DEG_SCF_FBW7_2	0.25
p.P309S	TCGA-GN-A9SD	SKCM	TCGA	LKTPPVE	DEG_SCF_FBW7_2	0.5641
p.P309L	TCGA-GN-A9SD	SKCM	TCGA	LKTPPVE	DEG_SCF_FBW7_2	0.6471
p.S314L	TCGA-IB-7651	PAAD	TCGA	LKTPPVE	DEG_SCF_FBW7_2	0.25
p.R302C	DO10276	COAD	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.25
p.R302C	DO233697	GACA	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.25
p.R302C	DO25737	LUAD	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.25
p.R302C	DO232761	PBCA	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.25
p.R302C	DO42608	UCEC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.25
p.A297S	DO219219	LUSC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.1111
p.A297S	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	LKTPPVE	DEG_SCF_FBW7_2	0.1111
p.R318G	DO219446	PRAD	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.1389
p.T320I	DO220197	SARC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.0833
p.E319K	DO50284	SKCM	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.1111
p.E319K	DO223910	SKCM	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.1111
p.N312S	DO51281	SKCM	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.3056
p.E306D	DO41235	UCEC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.6758
p.H304Y	DO42528	UCEC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	0.3056
p.S298L	ACH-000593	Bladder Cancer	CCLE	LKTPPVE	DEG_SCF_FBW7_2	0.5833
p.T307I	ACH-001495	Endometrial/Uterine Cancer	CCLE	LKTPPVE	DEG_SCF_FBW7_2	0.7078
p.E319V	PC-3_[JPC-3]	lung	COSMIC	LKTPPVE	DEG_SCF_FBW7_2	0.1111
p.V297M	H2804	pleura	COSMIC	LKTPPVE	DEG_SCF_FBW7_2	0.1111
p.E299A	KOSC-2	upper_aerodigestive_tract	COSMIC	LKTPPVE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFW9	Rab effector MyRIP	DEG_SCF_FBW7_2	305:311	LKTPPVE	FBXW7	0.9855	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons