DegronMD - Q8NFW9(MYRIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E302D	TCGA-A5-A2K5	UCEC	TCGA	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.25
p.R583Q	TCGA-BR-7196	STAD	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.6218
p.S601L	TCGA-D3-A5GU	SKCM	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0556
p.E589K	TCGA-D5-6539	COAD	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.591
p.E589K	TCGA-D9-A6EA	SKCM	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.591
p.E589K	TCGA-FW-A3R5	SKCM	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.591
p.R583W	TCGA-EJ-7782	PRAD	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.7523
p.R583W	TCGA-F1-6177	STAD	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.7523
p.P309S	TCGA-GN-A9SD	SKCM	TCGA	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation altering degron motif	0.5641
p.P309L	TCGA-GN-A9SD	SKCM	TCGA	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation altering degron motif	0.6471
p.S314L	TCGA-IB-7651	PAAD	TCGA	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.25
p.R600S	DO1873	BRCA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0833
p.R302C	DO10276	COAD	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.25
p.R302C	DO233697	GACA	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.25
p.R302C	DO25737	LUAD	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.25
p.R302C	DO232761	PBCA	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.25
p.R302C	DO42608	UCEC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.25
p.R590H	DO9708	COAD	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.8244
p.R590C	DO233898	GACA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.8301
p.R590C	DO43907	UCEC	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation altering degron motif	0.8301
p.R574L	DO229015	LICA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0833
p.D596Y	DO229035	LICA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1944
p.A297S	DO219219	LUSC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.1111
p.A297S	TUR	haematopoietic and lymphoid tissue	COSMIC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.1111
p.R600K	DO220877	MELA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0833
p.R600K	DO220891	MELA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0833
p.R318G	DO219446	PRAD	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.1389
p.T320I	DO220197	SARC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.0833
p.D596N	DO37798	SKCM	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1944
p.E319K	DO50284	SKCM	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.1111
p.E319K	DO223910	SKCM	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.1111
p.R595Q	DO38111	SKCM	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.2222
p.N312S	DO51281	SKCM	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.3056
p.E306D	DO41235	UCEC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation altering degron motif	0.6758
p.H304Y	DO42528	UCEC	ICGC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.3056
p.S600F	SIDM00336	Melanoma	GDSC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0833
p.S600F	ACH-000881	Skin Cancer	CCLE	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0833
p.S600F	MEL-JUSO	skin	COSMIC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0833
p.S298L	ACH-000593	Bladder Cancer	CCLE	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation blocking phosphorylation signal	0.5833
p.T307I	ACH-001495	Endometrial/Uterine Cancer	CCLE	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation altering degron motif	0.7078
p.E598K	ACH-002396	Bone Cancer	CCLE	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1389
p.E598K	Sarc9371	bone	COSMIC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.1389
p.E319V	PC-3_[JPC-3]	lung	COSMIC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.1111
p.V297M	H2804	pleura	COSMIC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.1111
p.E299A	KOSC-2	upper aerodigestive tract	COSMIC	LKTPPVE	DEG_SCF_FBW7_2	305:311	Mutation rewiring degron network	0.1667
p.G573E	MZ2-MEL	skin	COSMIC	RRNRLYELA	DEG_APCC_DBOX_1	583:591	Mutation rewiring degron network	0.0556

Kaplan plot for MYRIP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYRIP

UniProt ID: Q8NFW9

Entrez ID: 25924

Protein name: Rab effector MyRIP (Exophilin-8) (Myosin-VIIa- and Rab-interacting protein) (Synaptotagmin-like protein lacking C2 domains C) (SlaC2-c) (Slp homolog lacking C2 domains c)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYRIP in