DegronMD

Uniprot ID: Q8NFW9

Source protein: Rab effector MyRIP

Source gene: MYRIP

Class: DEG_APCC_DBOX_1

Location: 583:591

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.869

ASA_SCORE: 100.1778

COIL: 0.0849

CONS_SCORE: 0.7218

DSS_SCORE: 0.6109

HELIX: 0.918

FCONS_SCORE: 1.2428

RIG_SCORE: 0.7718

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R583Q	TCGA-BR-7196	STAD	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	0.6218
p.S601L	TCGA-D3-A5GU	SKCM	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	0.0556
p.E589K	TCGA-D5-6539	COAD	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	0.591
p.E589K	TCGA-D9-A6EA	SKCM	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	0.591
p.E589K	TCGA-FW-A3R5	SKCM	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	0.591
p.R583W	TCGA-EJ-7782	PRAD	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	0.7523
p.R583W	TCGA-F1-6177	STAD	TCGA	RRNRLYELA	DEG_APCC_DBOX_1	0.7523
p.R600S	DO1873	BRCA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.0833
p.R590H	DO9708	COAD	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.8244
p.R590C	DO233898	GACA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.8301
p.R590C	DO43907	UCEC	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.8301
p.R574L	DO229015	LICA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.0833
p.D596Y	DO229035	LICA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.1944
p.R600K	DO220877	MELA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.0833
p.R600K	DO220891	MELA	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.0833
p.D596N	DO37798	SKCM	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.1944
p.R595Q	DO38111	SKCM	ICGC	RRNRLYELA	DEG_APCC_DBOX_1	0.2222
p.S600F	SIDM00336	Melanoma	GDSC	RRNRLYELA	DEG_APCC_DBOX_1	0.0833
p.S600F	ACH-000881	Skin Cancer	CCLE	RRNRLYELA	DEG_APCC_DBOX_1	0.0833
p.S600F	MEL-JUSO	skin	COSMIC	RRNRLYELA	DEG_APCC_DBOX_1	0.0833
p.E598K	ACH-002396	Bone Cancer	CCLE	RRNRLYELA	DEG_APCC_DBOX_1	0.1389
p.E598K	Sarc9371	bone	COSMIC	RRNRLYELA	DEG_APCC_DBOX_1	0.1389
p.G573E	MZ2-MEL	skin	COSMIC	RRNRLYELA	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFW9	Rab effector MyRIP	DEG_APCC_DBOX_1	583:591	RRNRLYELA	APC,CDC20,FZR1	0.869	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons