DegronMD

Uniprot ID: P11586

Source protein: C-1-tetrahydrofolate synthase, cytoplasmic

Source gene: MTHFD1

Class: DEG_SCF_FBW7_1

Location: 312:318

E3 ligase: FBXW7

DEGRON score: 0.7935

ASA_SCORE: 82.5143

COIL: 0.9023

CONS_SCORE: 0.4777

DSS_SCORE: 0.2785

HELIX: 0.0434

FCONS_SCORE: 1.1227

RIG_SCORE: 0.7678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N308T	DO23458	LINC	ICGC	LKTPVPS	DEG_SCF_FBW7_1	0.2222
p.W303L	DO229275	THCA	ICGC	LKTPVPS	DEG_SCF_FBW7_1	0.0833
p.S322N	ACH-000292	Lung Cancer	CCLE	LKTPVPS	DEG_SCF_FBW7_1	0.2222
p.S322N	NCI-H841	lung	COSMIC	LKTPVPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11586	C-1-tetrahydrofolate synthase, cytoplasmic	DEG_SCF_FBW7_1	312:318	LKTPVPS	FBXW7	0.7935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons