DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
LKVYQD
Uniprot ID:
Q9C0G6
Source protein:
Dynein axonemal heavy chain 6
Source gene:
DNAH6
Class:
LIG_APCC_ABBA_1
Location:
78:83
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8585
ASA_SCORE:
95.9333
COIL:
0.6908
CONS_SCORE:
0.2735
DSS_SCORE:
0.3614
HELIX:
0.2432
FCONS_SCORE:
1.0766
RIG_SCORE:
0.7855
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DNAH6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LKVYQD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C0G6
Dynein axonemal heavy chain 6
LIG_APCC_ABBA_1
78:83
LKVYQD
APC,CDC20,FZR1
0.8585
More...