DegronMD

Uniprot ID: Q96DN2

Source protein: von Willebrand factor C and EGF domain-containing protein

Source gene: VWCE

Class: DEG_SCF_FBW7_1

Location: 340:347

E3 ligase: FBXW7

DEGRON score: 0.5063

ASA_SCORE: 65.05

COIL: 0.819

CONS_SCORE: 0.3625

DSS_SCORE: 0.2371

HELIX: 0.0948

FCONS_SCORE: 0.8552

RIG_SCORE: 0.7885

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P330S	TCGA-BF-A1Q0	SKCM	TCGA	LLATPVPT	DEG_SCF_FBW7_1	0.0556
p.P330S	TCGA-EE-A29D	SKCM	TCGA	LLATPVPT	DEG_SCF_FBW7_1	0.0556
p.P330S	DO47374	SKCM	ICGC	LLATPVPT	DEG_SCF_FBW7_1	0.0556
p.P330S	DO38123	SKCM	ICGC	LLATPVPT	DEG_SCF_FBW7_1	0.0556
p.G352W	TCGA-CR-7398	HNSC	TCGA	LLATPVPT	DEG_SCF_FBW7_1	0.1944
p.G352W	TCGA-FS-A1ZQ	SKCM	TCGA	LLATPVPT	DEG_SCF_FBW7_1	0.1944
p.G352W	DO14782	HNSC	ICGC	LLATPVPT	DEG_SCF_FBW7_1	0.1944
p.G352W	DO37442	SKCM	ICGC	LLATPVPT	DEG_SCF_FBW7_1	0.1944
p.S342T	DO233708	GACA	ICGC	LLATPVPT	DEG_SCF_FBW7_1	0.7116
p.P332Q	DO229041	LICA	ICGC	LLATPVPT	DEG_SCF_FBW7_1	0.1111
p.L350Q	DO50908	LICA	ICGC	LLATPVPT	DEG_SCF_FBW7_1	0.25
p.S350F	DO25396	LUAD	ICGC	LLATPVPT	DEG_SCF_FBW7_1	0.25
p.P354H	DO41452	UCEC	ICGC	LLATPVPT	DEG_SCF_FBW7_1	0.1389
p.P330L	SIDM00296	Small Cell Lung Carcinoma	GDSC	LLATPVPT	DEG_SCF_FBW7_1	0.0556
p.P330L	ACH-002051	Lung Cancer	CCLE	LLATPVPT	DEG_SCF_FBW7_1	0.0556
p.P330L	LU-134-A	lung	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	0.0556
p.I334N	UDSCC2	upper_aerodigestive_tract	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	0.1667
p.G345V	NB12	autonomic_ganglia	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	0.7532
p.G345W	NB12	autonomic_ganglia	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	0.7825
p.S344F	D-245MG	central_nervous_system	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DN2	von Willebrand factor C and EGF domain-containing protein	DEG_SCF_FBW7_1	340:347	LLATPVPT	FBXW7	0.5063	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons