DegronMD - Q96DN2(VWCE)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P787Q	TCGA-28-5211	GBM	TCGA	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.1944
p.S885F	TCGA-55-7907	LUAD	TCGA	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.0556
p.P787T	TCGA-66-2795	LUSC	TCGA	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.1944
p.S782C	TCGA-AC-A23H	BRCA	TCGA	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.0556
p.S782C	DO2401	BRCA	ICGC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.0556
p.P858H	TCGA-AX-A2HD	UCEC	TCGA	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.0556
p.P858H	DO42608	UCEC	ICGC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.0556
p.P330S	TCGA-BF-A1Q0	SKCM	TCGA	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.0556
p.P330S	TCGA-EE-A29D	SKCM	TCGA	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.0556
p.P330S	DO47374	SKCM	ICGC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.0556
p.P330S	DO38123	SKCM	ICGC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.0556
p.G352W	TCGA-CR-7398	HNSC	TCGA	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1944
p.G352W	TCGA-FS-A1ZQ	SKCM	TCGA	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1944
p.G352W	DO14782	HNSC	ICGC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1944
p.G352W	DO37442	SKCM	ICGC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1944
p.P865S	TCGA-D3-A5GR	SKCM	TCGA	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.25
p.P865S	DO47436	SKCM	ICGC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.25
p.L859V	TCGA-D8-A1XL	BRCA	TCGA	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.0833
p.L859V	DO1648	BRCA	ICGC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.0833
p.P862Q	TCGA-ER-A19T	SKCM	TCGA	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.1667
p.S885Y	TCGA-ND-A4WC	UCS	TCGA	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.0556
p.P784S	TCGA-VS-A9UI	CESC	TCGA	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.1111
p.P784S	DO219734	CESC	ICGC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.1111
p.S342T	DO233708	GACA	ICGC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation altering degron motif	0.7116
p.A881D	DO229015	LICA	ICGC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.1667
p.P332Q	DO229041	LICA	ICGC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1111
p.L350Q	DO50908	LICA	ICGC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.25
p.S350F	DO25396	LUAD	ICGC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.25
p.P354H	DO41452	UCEC	ICGC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.T788K	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.2222
p.T788K	SIDM00857	Melanoma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.2222
p.T788K	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.2222
p.T788K	SIDM01424	B-Lymphoblastic Leukemia	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.2222
p.V795M	SIDM00129	Melanoma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.6097
p.V795M	ACH-002121	Skin Cancer	CCLE	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.6097
p.V795M	G-MEL	skin	COSMIC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation altering degron motif	0.6097
p.S879F	SIDM01021	Glioblastoma	GDSC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.2222
p.S879F	ACH-002223	Brain Cancer	CCLE	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.2222
p.S879F	D-245MG	central nervous system	COSMIC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.2222
p.G880V	SIDM00258	Neuroblastoma	GDSC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.1944
p.G880V	ACH-002279	Neuroblastoma	CCLE	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.1944
p.G880V	NB12	autonomic ganglia	COSMIC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.1944
p.G880W	SIDM00258	Neuroblastoma	GDSC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.1944
p.G880W	ACH-002279	Neuroblastoma	CCLE	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.1944
p.G880W	NB12	autonomic ganglia	COSMIC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.1944
p.A864S	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.2222
p.A864S	ACH-000766	Lung Cancer	CCLE	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.2222
p.A864S	NCI-H1648	lung	COSMIC	PPVTPERS	DEG_SCF_FBW7_1	868:875	Mutation rewiring degron network	0.2222
p.P330L	SIDM00296	Small Cell Lung Carcinoma	GDSC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.0556
p.P330L	ACH-002051	Lung Cancer	CCLE	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.0556
p.P330L	LU-134-A	lung	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.0556
p.M808I	SIDM00640	Mesothelioma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.1111
p.M808I	ACH-000335	Lung Cancer	CCLE	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.1111
p.M808I	MSTO-211H	pleura	COSMIC	SRPVLHLLQ	DEG_APCC_DBOX_1	792:800	Mutation rewiring degron network	0.1111
p.I334N	UDSCC2	upper aerodigestive tract	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1667
p.G345V	NB12	autonomic ganglia	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation altering degron motif	0.7532
p.G345W	NB12	autonomic ganglia	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation altering degron motif	0.7825
p.S344F	D-245MG	central nervous system	COSMIC	LLATPVPT	DEG_SCF_FBW7_1	340:347	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VWCE

UniProt ID: Q96DN2

Entrez ID: 220001

Protein name: von Willebrand factor C and EGF domain-containing protein (HBV X protein up-regulated gene 11 protein) (HBxAg up-regulated gene 11 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VWCE in