DegronMD

Uniprot ID: Q96DN2

Source protein: von Willebrand factor C and EGF domain-containing protein

Source gene: VWCE

Class: DEG_APCC_DBOX_1

Location: 792:800

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6228

ASA_SCORE: 83.3667

COIL: 0.6788

CONS_SCORE: 0.4645

DSS_SCORE: 0.4432

HELIX: 0.1413

FCONS_SCORE: 0.9065

RIG_SCORE: 0.8087

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V795M	SIDM00129	Melanoma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.6097
p.V795M	ACH-002121	Skin Cancer	CCLE	SRPVLHLLQ	DEG_APCC_DBOX_1	0.6097
p.V795M	G-MEL	skin	COSMIC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.6097
p.T788K	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.2222
p.T788K	SIDM00857	Melanoma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.2222
p.T788K	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.2222
p.T788K	SIDM01424	B-Lymphoblastic Leukemia	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.2222
p.P787Q	TCGA-28-5211	GBM	TCGA	SRPVLHLLQ	DEG_APCC_DBOX_1	0.1944
p.P787T	TCGA-66-2795	LUSC	TCGA	SRPVLHLLQ	DEG_APCC_DBOX_1	0.1944
p.P784S	TCGA-VS-A9UI	CESC	TCGA	SRPVLHLLQ	DEG_APCC_DBOX_1	0.1111
p.P784S	DO219734	CESC	ICGC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.1111
p.M808I	SIDM00640	Mesothelioma	GDSC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.1111
p.M808I	ACH-000335	Lung Cancer	CCLE	SRPVLHLLQ	DEG_APCC_DBOX_1	0.1111
p.M808I	MSTO-211H	pleura	COSMIC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.1111
p.S782C	TCGA-AC-A23H	BRCA	TCGA	SRPVLHLLQ	DEG_APCC_DBOX_1	0.0556
p.S782C	DO2401	BRCA	ICGC	SRPVLHLLQ	DEG_APCC_DBOX_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DN2	von Willebrand factor C and EGF domain-containing protein	DEG_APCC_DBOX_1	792:800	SRPVLHLLQ	APC,CDC20,FZR1	0.6228	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons