DegronMD

Uniprot ID: Q96DN2

Source protein: von Willebrand factor C and EGF domain-containing protein

Source gene: VWCE

Class: DEG_SCF_FBW7_1

Location: 868:875

E3 ligase: FBXW7

DEGRON score: 0.9888

ASA_SCORE: 91.4875

COIL: 0.917

CONS_SCORE: 0.5284

DSS_SCORE: 0.6921

HELIX: 0.0355

FCONS_SCORE: 1.3347

RIG_SCORE: 0.6283

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S885F	TCGA-55-7907	LUAD	TCGA	PPVTPERS	DEG_SCF_FBW7_1	0.0556
p.P858H	TCGA-AX-A2HD	UCEC	TCGA	PPVTPERS	DEG_SCF_FBW7_1	0.0556
p.P858H	DO42608	UCEC	ICGC	PPVTPERS	DEG_SCF_FBW7_1	0.0556
p.P865S	TCGA-D3-A5GR	SKCM	TCGA	PPVTPERS	DEG_SCF_FBW7_1	0.25
p.P865S	DO47436	SKCM	ICGC	PPVTPERS	DEG_SCF_FBW7_1	0.25
p.L859V	TCGA-D8-A1XL	BRCA	TCGA	PPVTPERS	DEG_SCF_FBW7_1	0.0833
p.L859V	DO1648	BRCA	ICGC	PPVTPERS	DEG_SCF_FBW7_1	0.0833
p.P862Q	TCGA-ER-A19T	SKCM	TCGA	PPVTPERS	DEG_SCF_FBW7_1	0.1667
p.S885Y	TCGA-ND-A4WC	UCS	TCGA	PPVTPERS	DEG_SCF_FBW7_1	0.0556
p.A881D	DO229015	LICA	ICGC	PPVTPERS	DEG_SCF_FBW7_1	0.1667
p.S879F	SIDM01021	Glioblastoma	GDSC	PPVTPERS	DEG_SCF_FBW7_1	0.2222
p.S879F	ACH-002223	Brain Cancer	CCLE	PPVTPERS	DEG_SCF_FBW7_1	0.2222
p.S879F	D-245MG	central_nervous_system	COSMIC	PPVTPERS	DEG_SCF_FBW7_1	0.2222
p.G880V	SIDM00258	Neuroblastoma	GDSC	PPVTPERS	DEG_SCF_FBW7_1	0.1944
p.G880V	ACH-002279	Neuroblastoma	CCLE	PPVTPERS	DEG_SCF_FBW7_1	0.1944
p.G880V	NB12	autonomic_ganglia	COSMIC	PPVTPERS	DEG_SCF_FBW7_1	0.1944
p.G880W	SIDM00258	Neuroblastoma	GDSC	PPVTPERS	DEG_SCF_FBW7_1	0.1944
p.G880W	ACH-002279	Neuroblastoma	CCLE	PPVTPERS	DEG_SCF_FBW7_1	0.1944
p.G880W	NB12	autonomic_ganglia	COSMIC	PPVTPERS	DEG_SCF_FBW7_1	0.1944
p.A864S	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PPVTPERS	DEG_SCF_FBW7_1	0.2222
p.A864S	ACH-000766	Lung Cancer	CCLE	PPVTPERS	DEG_SCF_FBW7_1	0.2222
p.A864S	NCI-H1648	lung	COSMIC	PPVTPERS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96DN2	von Willebrand factor C and EGF domain-containing protein	DEG_SCF_FBW7_1	868:875	PPVTPERS	FBXW7	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons