DegronMD

Uniprot ID: Q6N021

Source protein: Methylcytosine dioxygenase TET2

Source gene: TET2

Class: DEG_SCF_FBW7_1

Location: 1119:1126

E3 ligase: FBXW7

DEGRON score: 0.9717

ASA_SCORE: 80.6375

COIL: 0.8044

CONS_SCORE: 0.3568

DSS_SCORE: 0.2605

HELIX: 0.13

FCONS_SCORE: 0.7942

RIG_SCORE: 0.809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1119V	TCGA-E6-A1LX	UCEC	TCGA	LLDTPVKT	DEG_SCF_FBW7_1	0.5654
p.L1119V	DO41020	UCEC	ICGC	LLDTPVKT	DEG_SCF_FBW7_1	0.5654
p.T1126I	DO50452	ESAD	ICGC	LLDTPVKT	DEG_SCF_FBW7_1	0.7078
p.C1135F	DO229031	LICA	ICGC	LLDTPVKT	DEG_SCF_FBW7_1	0.0833
p.K1117E	SIDM00291	Melanoma	GDSC	LLDTPVKT	DEG_SCF_FBW7_1	0.2778
p.K1117E	ACH-002040	Skin Cancer	CCLE	LLDTPVKT	DEG_SCF_FBW7_1	0.2778
p.K1117E	HMV-II	skin	COSMIC	LLDTPVKT	DEG_SCF_FBW7_1	0.2778
p.C1135Y	ACH-000687	Lymphoma	CCLE	LLDTPVKT	DEG_SCF_FBW7_1	0.0833
p.T1114I	ACH-001786	Colon/Colorectal Cancer	CCLE	LLDTPVKT	DEG_SCF_FBW7_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6N021	Methylcytosine dioxygenase TET2	DEG_SCF_FBW7_1	1119:1126	LLDTPVKT	FBXW7	0.9717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons