DegronMD - Q6N021(TET2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1119V	TCGA-E6-A1LX	UCEC	TCGA	LLDTPVKT	DEG_SCF_FBW7_1	1119:1126	Mutation altering degron motif	0.5654
p.L1119V	DO41020	UCEC	ICGC	LLDTPVKT	DEG_SCF_FBW7_1	1119:1126	Mutation altering degron motif	0.5654
p.T1126I	DO50452	ESAD	ICGC	LLDTPVKT	DEG_SCF_FBW7_1	1119:1126	Mutation altering degron motif	0.7078
p.C1135F	DO229031	LICA	ICGC	LLDTPVKT	DEG_SCF_FBW7_1	1119:1126	Mutation rewiring degron network	0.0833
p.H1778Y	DO222423	MELA	ICGC	NKEND	DEG_APCC_KENBOX_2	1784:1788	Mutation rewiring degron network	0.1667
p.H1778Y	DO37425	SKCM	ICGC	NKEND	DEG_APCC_KENBOX_2	1784:1788	Mutation rewiring degron network	0.1667
p.K1117E	SIDM00291	Melanoma	GDSC	LLDTPVKT	DEG_SCF_FBW7_1	1119:1126	Mutation rewiring degron network	0.2778
p.K1117E	ACH-002040	Skin Cancer	CCLE	LLDTPVKT	DEG_SCF_FBW7_1	1119:1126	Mutation rewiring degron network	0.2778
p.K1117E	HMV-II	skin	COSMIC	LLDTPVKT	DEG_SCF_FBW7_1	1119:1126	Mutation rewiring degron network	0.2778
p.C1135Y	ACH-000687	Lymphoma	CCLE	LLDTPVKT	DEG_SCF_FBW7_1	1119:1126	Mutation rewiring degron network	0.0833
p.T1114I	ACH-001786	Colon/Colorectal Cancer	CCLE	LLDTPVKT	DEG_SCF_FBW7_1	1119:1126	Mutation blocking phosphorylation signal	0.6389
p.G1775S	OVKATE	ovary	COSMIC	NKEND	DEG_APCC_KENBOX_2	1784:1788	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons