DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
NKEND
Uniprot ID:
Q6N021
Source protein:
Methylcytosine dioxygenase TET2
Source gene:
TET2
Class:
DEG_APCC_KENBOX_2
Location:
1784:1788
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8206
ASA_SCORE:
101.3
COIL:
0.8222
CONS_SCORE:
0.3519
DSS_SCORE:
0.45
HELIX:
0.1524
FCONS_SCORE:
0.9415
RIG_SCORE:
0.7065
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H1778Y
DO222423
MELA
ICGC
NKEND
DEG_APCC_KENBOX_2
0.1667
p.H1778Y
DO37425
SKCM
ICGC
NKEND
DEG_APCC_KENBOX_2
0.1667
p.G1775S
OVKATE
ovary
COSMIC
NKEND
DEG_APCC_KENBOX_2
0.0833
Drug responses associated with TET2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NKEND
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P30307
M-phase inducer phosphatase 3
DEG_APCC_KENBOX_2
150:154
NKEND
APC,CDC20,FZR1
0.9971
More...
Q6N021
Methylcytosine dioxygenase TET2
DEG_APCC_KENBOX_2
1784:1788
NKEND
APC,CDC20,FZR1
0.8206
More...