DegronMD

Uniprot ID: P30307

Source protein: M-phase inducer phosphatase 3

Source gene: CDC25C

Class: DEG_APCC_KENBOX_2

Location: 150:154

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9971

ASA_SCORE: 100.28

COIL: 0.8176

CONS_SCORE: 0.3337

DSS_SCORE: 0.5086

HELIX: 0.1304

FCONS_SCORE: 1.0689

RIG_SCORE: 0.63

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K140E	SIDM00931	Thyroid Gland Carcinoma	GDSC	NKEND	DEG_APCC_KENBOX_2	0.1667
p.K140E	ACH-000174	Thyroid Cancer	CCLE	NKEND	DEG_APCC_KENBOX_2	0.1667
p.K140E	CAL-62	thyroid	COSMIC	NKEND	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30307	M-phase inducer phosphatase 3	DEG_APCC_KENBOX_2	150:154	NKEND	APC,CDC20,FZR1	0.9971	More...
Q6N021	Methylcytosine dioxygenase TET2	DEG_APCC_KENBOX_2	1784:1788	NKEND	APC,CDC20,FZR1	0.8206	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons