DegronMD - P30307(CDC25C)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P215Q	TCGA-50-7109	LUAD	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1389
p.P215Q	DO24487	LUAD	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1389
p.E81D	TCGA-78-7536	LUAD	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.6758
p.E81D	DO26414	LUAD	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.6758
p.N235S	TCGA-A5-A0G2	UCEC	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1944
p.N235S	DO41235	UCEC	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1944
p.L87I	TCGA-AA-3949	COAD	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.L87I	DO7798	COAD	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.E219D	TCGA-AG-A002	READ	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.E219D	DO222884	COCA	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.D36Y	TCGA-AX-A2HC	UCEC	TCGA	QRKMLNLLL	DEG_APCC_DBOX_1	25:33	Mutation rewiring degron network	0.25
p.D36Y	DO41572	UCEC	ICGC	QRKMLNLLL	DEG_APCC_DBOX_1	25:33	Mutation rewiring degron network	0.25
p.L33P	TCGA-BG-A0LX	UCEC	TCGA	QRKMLNLLL	DEG_APCC_DBOX_1	25:33	Mutation altering degron motif	0.6471
p.L33P	DO41919	UCEC	ICGC	QRKMLNLLL	DEG_APCC_DBOX_1	25:33	Mutation altering degron motif	0.6471
p.D73N	TCGA-BR-6452	STAD	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.25
p.D73N	TCGA-EO-A22R	UCEC	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.25
p.D73N	DO38404	STAD	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.25
p.D73N	DO42713	UCEC	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.25
p.R213H	TCGA-BR-8680	STAD	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.R213H	TCGA-F5-6814	READ	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.R213H	DO36556	READ	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.R213H	DO47769	STAD	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.L87H	TCGA-DD-AACY	LIHC	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.L87H	DO219567	LIHC	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.N222K	TCGA-DD-AAE2	LIHC	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.5806
p.N222K	DO52256	LIHC	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.5806
p.L77R	TCGA-EB-A431	SKCM	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.7316
p.L77R	DO37671	SKCM	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.7316
p.L221S	TCGA-EO-A22T	UCEC	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.L221S	DO42320	UCEC	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.P218S	TCGA-FI-A2D5	UCEC	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.2222
p.P218S	DO41331	UCEC	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.2222
p.R213C	TCGA-FR-A726	SKCM	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.R213C	DO48665	SKCM	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.S214F	TCGA-FW-A3R5	SKCM	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation blocking phosphorylation signal	0.5556
p.S214F	DO37406	SKCM	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation blocking phosphorylation signal	0.5556
p.S75L	TCGA-FW-A3R5	SKCM	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation blocking phosphorylation signal	0.75
p.S75L	DO37406	SKCM	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation blocking phosphorylation signal	0.75
p.A91P	TCGA-K4-A4AC	BLCA	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.0556
p.A91P	DO542	BLCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.0556
p.S79N	TCGA-SJ-A6ZI	UCEC	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.5958
p.S79N	DO219784	UCEC	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.5958
p.T85I	TCGA-W3-AA1V	SKCM	TCGA	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.2222
p.T85I	DO51276	SKCM	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.2222
p.R70C	DO230315	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.R70C	DO230334	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.R70C	DO229010	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.R70C	DO229013	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.R70C	DO229016	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.R70C	DO229003	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.R70C	DO229005	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.R70C	DO230659	LAML	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.R70C	DO231140	LAML	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1667
p.D239N	DO234164	ESAD	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.S79G	DO231939	LICA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.6993
p.Q86H	DO228464	LICA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation rewiring degron network	0.1944
p.E34Q	SIDM00684	Glioblastoma	GDSC	QRKMLNLLL	DEG_APCC_DBOX_1	25:33	Mutation rewiring degron network	0.3056
p.E34Q	ACH-000595	Brain Cancer	CCLE	QRKMLNLLL	DEG_APCC_DBOX_1	25:33	Mutation rewiring degron network	0.3056
p.E34Q	LN-229	central nervous system	COSMIC	QRKMLNLLL	DEG_APCC_DBOX_1	25:33	Mutation rewiring degron network	0.3056
p.G80R	SIDM00129	Melanoma	GDSC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.7568
p.G80R	ACH-002121	Skin Cancer	CCLE	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.7568
p.G80R	G-MEL	skin	COSMIC	NLSSGE	DEG_Kelch_Keap1_1	76:81	Mutation altering degron motif	0.7568
p.K140E	SIDM00931	Thyroid Gland Carcinoma	GDSC	NKEND	DEG_APCC_KENBOX_2	150:154	Mutation substituting flanking lysine	0.1667
p.K140E	ACH-000174	Thyroid Cancer	CCLE	NKEND	DEG_APCC_KENBOX_2	150:154	Mutation substituting flanking lysine	0.1667
p.K140E	CAL-62	thyroid	COSMIC	NKEND	DEG_APCC_KENBOX_2	150:154	Mutation substituting flanking lysine	0.1667
p.D239H	SIDM01577	Plasma Cell Myeloma	GDSC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.D239H	ACH-000889	Myeloma	CCLE	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.V222M	SNU-175	large intestine	COSMIC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7208
p.G218D	GR-ST	haematopoietic and lymphoid tissue	COSMIC	NRPRLKQVE	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC25C

UniProt ID: P30307

Entrez ID: 995

Protein name: M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CDC25C in