DegronMD

Uniprot ID: P30307

Source protein: M-phase inducer phosphatase 3

Source gene: CDC25C

Class: DEG_APCC_DBOX_1

Location: 222:230

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9897

ASA_SCORE: 105.3222

COIL: 0.7126

CONS_SCORE: 0.3058

DSS_SCORE: 0.5829

HELIX: 0.2397

FCONS_SCORE: 1.0441

RIG_SCORE: 0.7424

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P215Q	TCGA-50-7109	LUAD	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.1389
p.P215Q	DO24487	LUAD	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.1389
p.N235S	TCGA-A5-A0G2	UCEC	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.1944
p.N235S	DO41235	UCEC	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.1944
p.E219D	TCGA-AG-A002	READ	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.25
p.E219D	DO222884	COCA	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.25
p.R213H	TCGA-BR-8680	STAD	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.0833
p.R213H	TCGA-F5-6814	READ	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.0833
p.R213H	DO36556	READ	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.0833
p.R213H	DO47769	STAD	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.0833
p.N222K	TCGA-DD-AAE2	LIHC	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.5806
p.N222K	DO52256	LIHC	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.5806
p.L221S	TCGA-EO-A22T	UCEC	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.3056
p.L221S	DO42320	UCEC	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.3056
p.P218S	TCGA-FI-A2D5	UCEC	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.2222
p.P218S	DO41331	UCEC	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.2222
p.R213C	TCGA-FR-A726	SKCM	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.0833
p.R213C	DO48665	SKCM	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.0833
p.S214F	TCGA-FW-A3R5	SKCM	TCGA	NRPRLKQVE	DEG_APCC_DBOX_1	0.5556
p.S214F	DO37406	SKCM	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.5556
p.D239N	DO234164	ESAD	ICGC	NRPRLKQVE	DEG_APCC_DBOX_1	0.0833
p.D239H	SIDM01577	Plasma Cell Myeloma	GDSC	NRPRLKQVE	DEG_APCC_DBOX_1	0.0833
p.D239H	ACH-000889	Myeloma	CCLE	NRPRLKQVE	DEG_APCC_DBOX_1	0.0833
p.V222M	SNU-175	large_intestine	COSMIC	NRPRLKQVE	DEG_APCC_DBOX_1	0.7208
p.G218D	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	NRPRLKQVE	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30307	M-phase inducer phosphatase 3	DEG_APCC_DBOX_1	222:230	NRPRLKQVE	APC,CDC20,FZR1	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons