DegronMD

Uniprot ID: P30307

Source protein: M-phase inducer phosphatase 3

Source gene: CDC25C

Class: DEG_APCC_DBOX_1

Location: 25:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9862

ASA_SCORE: 81.0889

COIL: 0.2792

CONS_SCORE: 0.3325

DSS_SCORE: 0.4265

HELIX: 0.6552

FCONS_SCORE: 1.0824

RIG_SCORE: 0.7863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D36Y	TCGA-AX-A2HC	UCEC	TCGA	QRKMLNLLL	DEG_APCC_DBOX_1	0.25
p.D36Y	DO41572	UCEC	ICGC	QRKMLNLLL	DEG_APCC_DBOX_1	0.25
p.L33P	TCGA-BG-A0LX	UCEC	TCGA	QRKMLNLLL	DEG_APCC_DBOX_1	0.6471
p.L33P	DO41919	UCEC	ICGC	QRKMLNLLL	DEG_APCC_DBOX_1	0.6471
p.E34Q	SIDM00684	Glioblastoma	GDSC	QRKMLNLLL	DEG_APCC_DBOX_1	0.3056
p.E34Q	ACH-000595	Brain Cancer	CCLE	QRKMLNLLL	DEG_APCC_DBOX_1	0.3056
p.E34Q	LN-229	central_nervous_system	COSMIC	QRKMLNLLL	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30307	M-phase inducer phosphatase 3	DEG_APCC_DBOX_1	25:33	QRKMLNLLL	APC,CDC20,FZR1	0.9862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons