DegronMD

Uniprot ID: P30307

Source protein: M-phase inducer phosphatase 3

Source gene: CDC25C

Class: DEG_Kelch_Keap1_1

Location: 76:81

E3 ligase: KEAP1

DEGRON score: 0.9314

ASA_SCORE: 80.4667

COIL: 0.7628

CONS_SCORE: 0.3053

DSS_SCORE: 0.3353

HELIX: 0.1922

FCONS_SCORE: 0.8596

RIG_SCORE: 0.6978

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E81D	TCGA-78-7536	LUAD	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.6758
p.E81D	DO26414	LUAD	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.6758
p.L87I	TCGA-AA-3949	COAD	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.L87I	DO7798	COAD	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.D73N	TCGA-BR-6452	STAD	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.25
p.D73N	TCGA-EO-A22R	UCEC	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.25
p.D73N	DO38404	STAD	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.25
p.D73N	DO42713	UCEC	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.25
p.L87H	TCGA-DD-AACY	LIHC	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.L87H	DO219567	LIHC	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.L77R	TCGA-EB-A431	SKCM	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.7316
p.L77R	DO37671	SKCM	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.7316
p.S75L	TCGA-FW-A3R5	SKCM	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.75
p.S75L	DO37406	SKCM	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.75
p.A91P	TCGA-K4-A4AC	BLCA	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.0556
p.A91P	DO542	BLCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.0556
p.S79N	TCGA-SJ-A6ZI	UCEC	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.5958
p.S79N	DO219784	UCEC	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.5958
p.T85I	TCGA-W3-AA1V	SKCM	TCGA	NLSSGE	DEG_Kelch_Keap1_1	0.2222
p.T85I	DO51276	SKCM	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.2222
p.R70C	DO230315	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R70C	DO230334	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R70C	DO229010	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R70C	DO229013	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R70C	DO229016	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R70C	DO229003	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R70C	DO229005	COCA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R70C	DO230659	LAML	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.R70C	DO231140	LAML	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1667
p.S79G	DO231939	LICA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.6993
p.Q86H	DO228464	LICA	ICGC	NLSSGE	DEG_Kelch_Keap1_1	0.1944
p.G80R	SIDM00129	Melanoma	GDSC	NLSSGE	DEG_Kelch_Keap1_1	0.7568
p.G80R	ACH-002121	Skin Cancer	CCLE	NLSSGE	DEG_Kelch_Keap1_1	0.7568
p.G80R	G-MEL	skin	COSMIC	NLSSGE	DEG_Kelch_Keap1_1	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NLSSGE

Degron related mutations and impact score

Drug responses associated with CDC25C mutations

All proteins holding degron of NLSSGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30307	M-phase inducer phosphatase 3	DEG_Kelch_Keap1_1	76:81	NLSSGE	KEAP1	0.9314	More...