DegronMD

Uniprot ID: Q9NPQ8

Source protein: Synembryn-A

Source gene: RIC8A

Class: LIG_APCC_ABBA_1

Location: 313:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6369

ASA_SCORE: 30.4667

COIL: 0.0265

CONS_SCORE: 0.6899

DSS_SCORE: 0.0311

HELIX: 0.9643

FCONS_SCORE: 1.3004

RIG_SCORE: 0.9678

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R311C	TCGA-04-1361	OV	TCGA	LLIFLE	LIG_APCC_ABBA_1	0.2778
p.R311C	TCGA-AA-A00N	COAD	TCGA	LLIFLE	LIG_APCC_ABBA_1	0.2778
p.R311C	DO9876	COAD	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.2778
p.R311C	DO32606	OV	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.2778
p.M303I	TCGA-28-5211	GBM	TCGA	LLIFLE	LIG_APCC_ABBA_1	0.0556
p.M303I	DO11016	GBM	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.0556
p.R320H	TCGA-86-6562	LUAD	TCGA	LLIFLE	LIG_APCC_ABBA_1	0.2778
p.R320H	DO24013	LUAD	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.2778
p.H322R	TCGA-AX-A2HJ	UCEC	TCGA	LLIFLE	LIG_APCC_ABBA_1	0.2222
p.H322R	DO42105	UCEC	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.2222
p.R311H	DO222526	ESCA	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.2778
p.M307I	DO228971	LICA	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.1667
p.R326M	DO229019	LICA	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.1111
p.I315L	DO221131	MALY	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.6063
p.R320C	DO42673	UCEC	ICGC	LLIFLE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPQ8	Synembryn-A	LIG_APCC_ABBA_1	313:318	LLIFLE	APC,CDC20,FZR1	0.6369	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons