DegronMD - Q9NPQ8(RIC8A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R311C	TCGA-04-1361	OV	TCGA	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2778
p.R311C	TCGA-AA-A00N	COAD	TCGA	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2778
p.R311C	DO9876	COAD	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2778
p.R311C	DO32606	OV	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2778
p.M303I	TCGA-28-5211	GBM	TCGA	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.0556
p.M303I	DO11016	GBM	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.0556
p.D494H	TCGA-5L-AAT1	BRCA	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.0833
p.R320H	TCGA-86-6562	LUAD	TCGA	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2778
p.R320H	DO24013	LUAD	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2778
p.I502V	TCGA-AP-A1DK	UCEC	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation blocking phosphorylation signal	0.75
p.I502V	DO42033	UCEC	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation blocking phosphorylation signal	0.75
p.R510Q	TCGA-AX-A1C5	UCEC	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.7329
p.H322R	TCGA-AX-A2HJ	UCEC	TCGA	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2222
p.H322R	DO42105	UCEC	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2222
p.T514M	TCGA-CG-4306	STAD	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.25
p.Q517H	TCGA-D3-A2JG	SKCM	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1667
p.Q517H	DO47613	SKCM	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1667
p.G506W	TCGA-E8-A2EA	THCA	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.7825
p.L516M	TCGA-EE-A29X	SKCM	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.L516M	DO37595	SKCM	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1944
p.P504S	TCGA-HU-A4H4	STAD	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.6752
p.P504S	DO47721	STAD	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.6752
p.R311H	DO222526	ESCA	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2778
p.M307I	DO228971	LICA	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1667
p.R326M	DO229019	LICA	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.1111
p.D518Y	DO229022	LICA	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1389
p.G506V	DO229031	LICA	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.7532
p.I315L	DO221131	MALY	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation altering degron motif	0.6063
p.T508M	DO38567	STAD	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.6312
p.G500W	DO38926	THCA	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.25
p.R504Q	DO41422	UCEC	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.7329
p.R320C	DO42673	UCEC	ICGC	LLIFLE	LIG_APCC_ABBA_1	313:318	Mutation rewiring degron network	0.2778
p.Q517R	SIDM00373	Endometrial Carcinoma	GDSC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1667
p.A519V	SIDM00282	Colorectal Carcinoma	GDSC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1111
p.A519V	CW-2	large intestine	COSMIC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.1111
p.Q511R	ACH-000974	Endometrial/Uterine Cancer	CCLE	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.6218
p.A513V	ACH-000998	Colon/Colorectal Cancer	CCLE	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2778
p.A513V	CW-2	large intestine	COSMIC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation rewiring degron network	0.2778
p.A507V	CW-2	large intestine	COSMIC	PRGHLTSLQ	DEG_APCC_DBOX_1	503:511	Mutation altering degron motif	0.6936

Kaplan plot for RIC8A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIC8A

UniProt ID: Q9NPQ8

Entrez ID: 60626

Protein name: Synembryn-A (Protein Ric-8A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIC8A in