DegronMD

Uniprot ID: Q9NPQ8

Source protein: Synembryn-A

Source gene: RIC8A

Class: DEG_APCC_DBOX_1

Location: 503:511

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8682

ASA_SCORE: 78.8444

COIL: 0.5852

CONS_SCORE: 0.2581

DSS_SCORE: 0.6054

HELIX: 0.2186

FCONS_SCORE: 0.9892

RIG_SCORE: 0.6883

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D494H	TCGA-5L-AAT1	BRCA	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	0.0833
p.I502V	TCGA-AP-A1DK	UCEC	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	0.75
p.I502V	DO42033	UCEC	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.75
p.R510Q	TCGA-AX-A1C5	UCEC	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	0.7329
p.T514M	TCGA-CG-4306	STAD	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	0.25
p.Q517H	TCGA-D3-A2JG	SKCM	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	0.1667
p.Q517H	DO47613	SKCM	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.1667
p.G506W	TCGA-E8-A2EA	THCA	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	0.7825
p.L516M	TCGA-EE-A29X	SKCM	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	0.1944
p.L516M	DO37595	SKCM	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.1944
p.P504S	TCGA-HU-A4H4	STAD	TCGA	PRGHLTSLQ	DEG_APCC_DBOX_1	0.6752
p.P504S	DO47721	STAD	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.6752
p.D518Y	DO229022	LICA	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.1389
p.G506V	DO229031	LICA	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.7532
p.T508M	DO38567	STAD	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.6312
p.G500W	DO38926	THCA	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.25
p.R504Q	DO41422	UCEC	ICGC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.7329
p.Q517R	SIDM00373	Endometrial Carcinoma	GDSC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.1667
p.A519V	SIDM00282	Colorectal Carcinoma	GDSC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.1111
p.A519V	CW-2	large_intestine	COSMIC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.1111
p.Q511R	ACH-000974	Endometrial/Uterine Cancer	CCLE	PRGHLTSLQ	DEG_APCC_DBOX_1	0.6218
p.A513V	ACH-000998	Colon/Colorectal Cancer	CCLE	PRGHLTSLQ	DEG_APCC_DBOX_1	0.2778
p.A513V	CW-2	large_intestine	COSMIC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.2778
p.A507V	CW-2	large_intestine	COSMIC	PRGHLTSLQ	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPQ8	Synembryn-A	DEG_APCC_DBOX_1	503:511	PRGHLTSLQ	APC,CDC20,FZR1	0.8682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons