DegronMD

Uniprot ID: Q70JA7

Source protein: Chondroitin sulfate synthase 3

Source gene: CHSY3

Class: LIG_APCC_ABBA_1

Location: 713:718

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5198

ASA_SCORE: 8.2667

COIL: 0.0887

CONS_SCORE: 0.6894

DSS_SCORE: 0.0146

HELIX: 0.0072

FCONS_SCORE: 1.2857

RIG_SCORE: 0.996

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L713S	DO222752	COCA	ICGC	LLLFCD	LIG_APCC_ABBA_1	0.7667
p.T712I	TCGA-BR-8059	STAD	TCGA	LLLFCD	LIG_APCC_ABBA_1	0.3056
p.T712I	DO38443	STAD	ICGC	LLLFCD	LIG_APCC_ABBA_1	0.3056
p.D720E	DO230451	UTCA	ICGC	LLLFCD	LIG_APCC_ABBA_1	0.2778
p.L721F	DO228743	LICA	ICGC	LLLFCD	LIG_APCC_ABBA_1	0.25
p.A706V	TCGA-AX-A2HD	UCEC	TCGA	LLLFCD	LIG_APCC_ABBA_1	0.1389
p.A706V	DO42608	UCEC	ICGC	LLLFCD	LIG_APCC_ABBA_1	0.1389
p.E725K	TCGA-DK-A6AW	BLCA	TCGA	LLLFCD	LIG_APCC_ABBA_1	0.1389
p.E725K	DO48566	BLCA	ICGC	LLLFCD	LIG_APCC_ABBA_1	0.1389
p.A706S	ACH-000786	Lymphoma	CCLE	LLLFCD	LIG_APCC_ABBA_1	0.1389
p.A704V	DO231893	LINC	ICGC	LLLFCD	LIG_APCC_ABBA_1	0.0833

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q70JA7	Chondroitin sulfate synthase 3	LIG_APCC_ABBA_1	713:718	LLLFCD	APC,CDC20,FZR1	0.5198	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons