DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LLLFCD
Uniprot ID:
Q70JA7
Source protein:
Chondroitin sulfate synthase 3
Source gene:
CHSY3
Class:
LIG_APCC_ABBA_1
Location:
713:718
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5198
ASA_SCORE:
8.2667
COIL:
0.0887
CONS_SCORE:
0.6894
DSS_SCORE:
0.0146
HELIX:
0.0072
FCONS_SCORE:
1.2857
RIG_SCORE:
0.996
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A706V
TCGA-AX-A2HD
UCEC
TCGA
LLLFCD
LIG_APCC_ABBA_1
0.1389
p.A706V
DO42608
UCEC
ICGC
LLLFCD
LIG_APCC_ABBA_1
0.1389
p.T712I
TCGA-BR-8059
STAD
TCGA
LLLFCD
LIG_APCC_ABBA_1
0.3056
p.T712I
DO38443
STAD
ICGC
LLLFCD
LIG_APCC_ABBA_1
0.3056
p.E725K
TCGA-DK-A6AW
BLCA
TCGA
LLLFCD
LIG_APCC_ABBA_1
0.1389
p.E725K
DO48566
BLCA
ICGC
LLLFCD
LIG_APCC_ABBA_1
0.1389
p.L713S
DO222752
COCA
ICGC
LLLFCD
LIG_APCC_ABBA_1
0.7667
p.L721F
DO228743
LICA
ICGC
LLLFCD
LIG_APCC_ABBA_1
0.25
p.A704V
DO231893
LINC
ICGC
LLLFCD
LIG_APCC_ABBA_1
0.0833
p.D720E
DO230451
UTCA
ICGC
LLLFCD
LIG_APCC_ABBA_1
0.2778
p.A706S
ACH-000786
Lymphoma
CCLE
LLLFCD
LIG_APCC_ABBA_1
0.1389
Drug responses associated with CHSY3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LLLFCD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q70JA7
Chondroitin sulfate synthase 3
LIG_APCC_ABBA_1
713:718
LLLFCD
APC,CDC20,FZR1
0.5198
More...