DegronMD

Uniprot ID: P12109

Source protein: Collagen alpha-1

Source gene: COL6A1

Class: LIG_APCC_ABBA_1

Location: 939:944

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8204

ASA_SCORE: 7.45

COIL: 0.1067

CONS_SCORE: 0.8701

DSS_SCORE: 0.3308

HELIX: 0.0083

FCONS_SCORE: 1.3864

RIG_SCORE: 0.8007

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G933S	TCGA-B5-A3FC	UCEC	TCGA	LLLFSD	LIG_APCC_ABBA_1	0.1667
p.G933S	DO41871	UCEC	ICGC	LLLFSD	LIG_APCC_ABBA_1	0.1667
p.Q948H	TCGA-CV-7090	HNSC	TCGA	LLLFSD	LIG_APCC_ABBA_1	0.2222
p.Q948H	DO14238	HNSC	ICGC	LLLFSD	LIG_APCC_ABBA_1	0.2222
p.A930V	TCGA-E6-A2P8	UCEC	TCGA	LLLFSD	LIG_APCC_ABBA_1	0.0833
p.A930V	DO40924	UCEC	ICGC	LLLFSD	LIG_APCC_ABBA_1	0.0833
p.A953V	TCGA-EY-A1GF	UCEC	TCGA	LLLFSD	LIG_APCC_ABBA_1	0.0833
p.A953V	DO41704	UCEC	ICGC	LLLFSD	LIG_APCC_ABBA_1	0.0833
p.A930S	DO228952	LICA	ICGC	LLLFSD	LIG_APCC_ABBA_1	0.0833
p.G933V	DO52655	MALY	ICGC	LLLFSD	LIG_APCC_ABBA_1	0.1667
p.A953T	DO224750	PACA	ICGC	LLLFSD	LIG_APCC_ABBA_1	0.0833
p.A953T	SIDM01608	Endometrial Carcinoma	GDSC	LLLFSD	LIG_APCC_ABBA_1	0.0833
p.S947L	SIDM00217	Colorectal Carcinoma	GDSC	LLLFSD	LIG_APCC_ABBA_1	0.25
p.S947L	ACH-000999	Colon/Colorectal Cancer	CCLE	LLLFSD	LIG_APCC_ABBA_1	0.25
p.P952A	SIDM01617	Endometrial Carcinoma	GDSC	LLLFSD	LIG_APCC_ABBA_1	0.1111
p.P952A	ACH-000994	Endometrial/Uterine Cancer	CCLE	LLLFSD	LIG_APCC_ABBA_1	0.1111
p.K937E	SIDM01664	Prostate Carcinoma	GDSC	LLLFSD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12109	Collagen alpha-1	LIG_APCC_ABBA_1	939:944	LLLFSD	APC,CDC20,FZR1	0.8204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons