DegronMD - P12109(COL6A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G933S	TCGA-B5-A3FC	UCEC	TCGA	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.1667
p.G933S	TCGA-B5-A3FC	UCEC	TCGA	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.1944
p.G933S	DO41871	UCEC	ICGC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.1667
p.G933S	DO41871	UCEC	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.1944
p.Q948H	TCGA-CV-7090	HNSC	TCGA	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.2222
p.Q948H	TCGA-CV-7090	HNSC	TCGA	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.2222
p.Q948H	DO14238	HNSC	ICGC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.2222
p.Q948H	DO14238	HNSC	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.2222
p.A930V	TCGA-E6-A2P8	UCEC	TCGA	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.A930V	TCGA-E6-A2P8	UCEC	TCGA	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.1111
p.A930V	DO40924	UCEC	ICGC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.A930V	DO40924	UCEC	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.1111
p.A953V	TCGA-EY-A1GF	UCEC	TCGA	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.A953V	TCGA-EY-A1GF	UCEC	TCGA	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.0833
p.A953V	DO41704	UCEC	ICGC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.A953V	DO41704	UCEC	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.0833
p.A930S	DO228952	LICA	ICGC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.A930S	DO228952	LICA	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.1111
p.G933V	DO52655	MALY	ICGC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.1667
p.G933V	DO52655	MALY	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.1944
p.A953T	DO224750	PACA	ICGC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.A953T	DO224750	PACA	ICGC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.0833
p.A953T	SIDM01608	Endometrial Carcinoma	GDSC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.0833
p.A953T	SIDM01608	Endometrial Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.0833
p.R928H	SIDM00773	Non-Cancerous	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.0556
p.R928H	SIDM01126	Small Cell Lung Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.0556
p.R928H	SIDM00203	Ewing's Sarcoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.0556
p.R928H	SIDM00774	Breast Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.0556
p.S947L	SIDM00217	Colorectal Carcinoma	GDSC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.25
p.S947L	SIDM00217	Colorectal Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.25
p.S947L	ACH-000999	Colon/Colorectal Cancer	CCLE	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.25
p.S947L	ACH-000999	Colon/Colorectal Cancer	CCLE	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.25
p.P952A	SIDM01617	Endometrial Carcinoma	GDSC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.1111
p.P952A	SIDM01617	Endometrial Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.1111
p.P952A	ACH-000994	Endometrial/Uterine Cancer	CCLE	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.1111
p.P952A	ACH-000994	Endometrial/Uterine Cancer	CCLE	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.1111
p.K937E	SIDM01664	Prostate Carcinoma	GDSC	LLLFSD	LIG_APCC_ABBA_1	939:944	Mutation rewiring degron network	0.2778
p.K937E	SIDM01664	Prostate Carcinoma	GDSC	RLLLFSD	LIG_APCC_ABBAyCdc20_2	938:944	Mutation rewiring degron network	0.3056

Kaplan plot for COL6A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL6A1

UniProt ID: P12109

Entrez ID: 1291

Protein name: Collagen alpha-1(VI) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL6A1 in